Sanofi Chlorprotixen, 15 mg 30 pcs

Antipsychotic agent (neuroleptic), derivative of thioxanthene. It has antipsychotic, antidepressant, sedative, antiemetic effects, has alpha-adrenoblocking activity.

It is believed that the antipsychotic action is associated with blockade of postsynaptic dopamine receptors in the brain. Antiemetic action is associated with blockade of chemoreceptor trigger zone of the medulla oblongata. Sedative action is caused by indirect weakening of activity of reticular system of brain stem.

It suppresses release of most hypothalamic and pituitary hormones. However, as a result of blockade of prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary gland, prolactin concentration increases.

The thioxanthenes are similar to the piperazine derivatives of phenothiazine in their chemical structure and pharmacological properties.

Indications

Chlorprothixene is a sedative antipsychotic with a wide range of indications, which include:
hyperactivity, irritability, agitation, confusion in elderly patients;
psychoses, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety;
“hangover” withdrawal syndrome in alcoholism and drug addiction;
depressive states, neuroses, psychosomatic disorders;
insomnia;
behavioral disorders in children;
pain (in combination with analgesics).

Pharmacological effect

Antipsychotic drug (neuroleptic), thioxanthene derivative. It has antipsychotic, antidepressant, sedative, antiemetic effects, and has alpha-adrenergic blocking activity.

It is believed that the antipsychotic effect is associated with blockade of postsynaptic dopamine receptors in the brain. The antiemetic effect is associated with blockade of the chemoreceptor trigger zone of the medulla oblongata. The sedative effect is due to an indirect weakening of the activity of the reticular system of the brain stem.

Suppresses the release of most hormones of the hypothalamus and pituitary gland. However, as a result of blockade of prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary gland, the concentration of prolactin increases.

The chemical structure and pharmacological properties of thioxanthenes are similar to piperazine derivatives of phenothiazine.

Special instructions

The use of Chlorprothixene may lead to a false positive result when conducting an immunobiological urine test for pregnancy, a false increase in the level of bilirubin in the blood, and a change in the QT interval on the electrocardiogram.

Active ingredient

Chlorprothixene

Composition

1 film-coated tablet contains:

Pregnancy

Chlorprothixene should, if possible, not be prescribed to pregnant women or during breastfeeding.

Contraindications

CNS depression of any origin (including those caused by alcohol, barbiturates or opiates);

Side Effects

Orthostatic hypotension may occur, especially when using Chlorprothixene in high dosages. Dry mouth, drowsiness, tachycardia, difficulty in accommodation, increased sweating. These side effects, which usually occur early in therapy, often disappear as therapy continues.

Interaction

The anticholinergic effect of chlorprothixene is enhanced by the simultaneous use of anticholinergic, antihistamine and antiparkinsonian drugs.

Overdose

Symptoms: hypo- or hyperthermia, drowsiness, convulsions, extrapyramidal symptoms, coma, shock. Treatment. Symptomatic and supportive.

Storage conditions

In a dry place, at a temperature of 10–25 °C

Shelf life

3 years

Manufacturer

Zentiva k.s., Czech Republic