Retinoic ointment, 0.05% 15 g

Isotretinoin is one of the biologically active forms of vitamin A.

It inhibits terminal differentiation of sebocytes and hyperproliferation of epithelium of sebaceous glands outlet ducts, normalizes the composition of their secret and facilitates its evacuation.

Indications

Acne vulgaris, seborrheic dermatitis, rosacea, perioral dermatitis.

Pharmacological effect

Pharmacotherapeutic group: tissue regeneration stimulator.

ATX code: (D10AD04)

Pharmacological properties
Isotretinoin is one of the biologically active forms of vitamin A. It inhibits the terminal differentiation of sebocytes and hyperproliferation of the epithelium of the excretory ducts of the sebaceous glands, normalizes the composition of their secretions and facilitates its evacuation. Due to this, sebum production is reduced and the inflammatory reaction around the glands is reduced. The ointment has an antiseborrheic, anti-inflammatory, keratolytic effect, enhances regeneration processes in the skin.

Special instructions

It is not recommended to apply the ointment to the skin around the eyes, or in cases of severe acute inflammation. Do not apply to mucous membranes. During treatment, you should avoid exposure to the sun; if necessary, use sunscreen; preventive and therapeutic use of ultraviolet rays and visiting a solarium are not recommended.
The drug does not affect the ability to drive a car or perform work that requires increased concentration.

Active ingredient

Isotretinoin

Composition

Active ingredient: isotretinoin 0.05 or 0.1 g.

Excipients: butylated hydroxytoluene – 0.05 g, butylated hydroxyanisole – 0.025 g, emulsion wax – 8.0 g, petroleum jelly – 8.0 g, glycerol (glycerin) – 10.0 g, ethanol (ethyl alcohol) 95% – 10.0 g, purified water up to 100 g.

Pregnancy

It is not recommended to apply to large areas of skin during pregnancy, breastfeeding and women planning pregnancy.

Contraindications

Use with caution in chronic diseases of the liver, kidneys, chronic pancreatitis, cardiac decompensation.

Side Effects

In the second week of treatment, an exacerbation reaction is possible – the appearance of new rashes, itching, redness and peeling of the skin. If the reaction is severe, it is recommended to stop treatment for several days until it subsides. In some cases, with individual sensitivity, maculopapular rashes, itching and swelling appear on the first or second day of use. In such cases, the drug should be discontinued. With prolonged use, symptoms of chronic hypervitaminosis A may develop (cheilitis, conjunctivitis, dryness and flaking of the skin).

Interaction

The ointment should not be prescribed to patients receiving other drugs from the retinoid group in order to reduce the risk of hypervitaminosis A. The effect of the ointment is weakened by simultaneous local use of glucocorticosteroids.

Storage conditions

At temperatures from 2 to 8 °C. Do not allow freezing. Keep out of the reach of children.

Shelf life

2 years. Do not use after expiration date.

Manufacturer

Retinoids JSC, Russia