Calcemin, 30 pcs.

Composite preparation containing vitamin DZ, micro- and macroelements. It regulates phosphorus-calcium metabolism, compensates relative deficit of microelements and vitamin DZ, prevents diseases of musculoskeletal system, promotes strengthening of bone system and joints.

Calcium contained in the preparation is a building component of bone tissue, regulates permeability of the vascular wall, participates in regulation of conductivity in synapses and neuro-muscular connections, participates in the contractile activity of skeletal and smooth muscles and is an essential component of blood clotting.

Calcium is presented in the product by carbonate and citrate salts. Calcium carbonate contains the maximum amount of elemental calcium. Calcium citrate reduces dependence of calcium bioavailability on state of gastrointestinal mucosa, prevents concrements formation in urinary system even in case of long-term use, reduces excessive production of parathormone.

Vitamin D (cholecalciferol) contributes to the adequate absorption of calcium, is involved in the process of regeneration and building bone tissue.
Zinc is an integral component of various body enzymes (over 200 species), which synthesize proteins and nucleic acids. It also ensures gene expression, regeneration and growth of cells. It positively influences the activity of the enzyme alkaline phosphatase.

Manganese promotes the synthesis of substances that are components of bone and cartilage tissue (glycosaminoglycans). Potentiates the calcium-saving ability of vitamin D.

Copper is involved in the formation of elastin, collagen. It helps to stop the phenomenon of demineralization of bone structures.
Boron normalizes the activity of hormone of the parathyroid gland – parathormone. The latter is involved in the metabolism of calcium, cholecalciferol, phosphorus and magnesium. Effect on mineral metabolism of parathormone does not depend on the intake of vitamin D3.

Indications

Bone fractures, osteoporosis, bone fragility

• Prevention and complex treatment of osteoporosis of different genesis:
• Filling the calcium and trace element deficiency in adolescents, women during pregnancy and lactation.
  

Composition

Active Ingredients:

Calcium 250 mg (calcium citrate and calcium carbonate),

Vitamin D3 (cholecalciferol) 50 ME,

Copper (copper oxide) 0.5 mg,

Zinc (zinc oxide) 2 mg,

Manganese (manganese sulfate) 0.5 mg,

Boron (sodium borate) 50 µg .

Inactive ingredients:

Maltodextrin,

Microcrystalline cellulose,

Crossamellose sodium,

acacia,

stearic acid,

soy polysaccharide,

magnesium stearate.

Shell:

Hypromellose 11, 71,

triacetin 2, 53 mg,

mineral oil 1, 27 mg,

sodium lauryl sulfate 0, 004 mg, 7, 03 mg,

magnesium silicate 5 mg.

Description:

The tablets are biconvex oval-shaped, coated white with a rib on one side.

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How to take, the dosage

Ingestion.

Children from 5 to 12 years old take 1 tablet. 1 time a day with meals.

Adults and children over 12 years of age – 1 tablet 2 times a day with meals.

When pregnant and breastfeeding: from the 20th week of pregnancy and during the whole period of breastfeeding – 1 tablet 2 times a day.

The minimal course of the preparation in case of osteoporosis in combination therapy for adults is 3 months; the longer course must be taken after consulting the doctor.

The minimal course of treatment with the preparation for prevention of osteoporosis in adults is 1 month; the longest course must be taken after consulting a doctor.

The minimal course of the preparation for children and adults in case of calcium and microelement deficiency is 2-3 months; the longer course must be taken after consulting a doctor.

The preparation can be repeated 1 month after the end of treatment.

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Interaction

In concomitant use of Calcemin with vitamin A toxicity of vitamin D3 is reduced. Phenytoin, barbiturates, GCS reduce the effectiveness of vitamin D3. Laxatives reduce absorption of vitamin D3. GCS, hormonal contraceptives for systemic use, levothyroxine impair absorption of calcium ions.

In case of concomitant use of tetracyclines the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) – at least 2 hours.

When Collaboration of Calcemin preparation with cardiac glycosides increases their toxicity (it is necessary to control ECG and clinical condition), with thiazide diuretics – the risk of hypercalcaemia increases, with furosemide and other loop diuretics – renal calcium excretion increases.

Calcemin should not be used simultaneously with calcium channel blockers. It is not recommended to use the preparation in combination with antacids containing aluminum due to decrease of their effectiveness.

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Special Instructions

The dose should not exceed the one indicated in the instructions because increased calcium intake may inhibit the absorption of iron, zinc, and other essential minerals in the intestine.

Contraindications

Hypersensitivity to any of the ingredients of the drug, hypercalcemia and hypercalciuria, nephrolthiasis, vitamin D3 hypervitaminosis, severe renal insufficiency, active tuberculosis, decalcifying tumors (myeloma, bone metastases, sarcoidosis), children under 5 years old.

With caution:

Benign granulomatosis, administration of cardiac glycosides and thiazide diuretics, pregnancy, period of lactation.

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Overdose

Symptoms: Possible constipation, nausea, and vomiting.

The manifestations of overdose also include hypercalcemia and hypercalciuria, leading to calcium accumulation in the soft tissues and irreversible changes in the kidneys and cardiovascular system.

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Pregnancy use

During pregnancy and breast-feeding the drug administration should be coordinated with the doctor.

The fixed dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3; hypergallcemia caused by overdose during pregnancy can cause defects in the mental and physical development of the fetus.

In breastfeeding women it should be taken into account that colecalciferol and its metabolites penetrate into the breast milk, so the intake of calcium and vitamin D3 must be considered.