Quetiapine, 100 mg 60 pcs

– Treatment of schizophrenia.

Active ingredient

Quetiapine

How to take, the dosage

Quetiapine can be used independently of food intake.

Interaction

Caution should be exercised when combining Quetiapine with other drugs affecting the central nervous system and with alcohol. Cytochrome P450 isoenzyme (CYP) ZA4 is the main isoenzyme responsible for the metabolism of quetiapine through the cytochrome P450 system.

Special Instructions

Drowsiness

Drowsiness and associated symptoms, such as sedation, may be noted during therapy with Quetiapine (see section “Side effects”). In clinical studies involving patients with depression in the structure of bipolar disorder, somnolence usually developed during the first three days of therapy. The severity of this side effect was generally mild to moderate. If severe somnolence develops, patients with depression in the structure of bipolar disorder may require more frequent visits to the physician within 2 weeks from the onset of somnolence or until the severity of symptoms decreases. In some cases, Quetiapine therapy may need to be discontinued.

Contraindications

Hypersensitivity to any of the ingredients of the drug, including lactase deficiency, glucose-galactose malabsorption and galactose intolerance.

Side effects

CNS disorders: headache, drowsiness, dizziness, anxiety; rarely – ANS.

Cardiovascular system: orthostatic hypotension, tachycardia, arterial hypertension.

Digestive system disorders: constipation, dry mouth, dyspepsia, diarrhea, transient increase of liver enzymes activity (ALT, AST, GGT), abdominal pain.

Hematopoietic organs: asymptomatic leukopenia and/or neutropenia; rarely – eosinophilia.

Muscular system disorders: myalgia.

Respiratory system: rhinitis.

Dermatological reactions: skin rash, dry skin.

Hearing organ: ear pain.

Treatment of the urinary system: urinary tract infections.

Metabolic side: slight increase in cholesterol and triglycerides in the blood.

Endocrine system disorders: slight dose-dependent reversible decrease of thyroid hormone levels (in particular total and free T₄).

Others: asthenia, low back pain, weight gain, fever, chest pain.

Overdose

A fatal outcome has been reported with 13.6 g of quetiapine in a patient participating in a clinical trial and a fatal outcome after taking 6 g of quetiapine in a post-marketing study of the drug.

Similarities

Seroquel, Seroquel Prolong, Quetiapine