Pyrogenal, 10 µg 1 ml 10 pcs

Pyrogenal is an immunomodulator of wide spectrum of action, the main of which are activation of reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. Pyrogenal has adjuvant, desensitizing and anti-inflammatory properties, increases general and specific resistance of the body, influences thermoregulatory centers of hypothalamus.

Stimulates the activity of hyaluronidase: increases tissue permeability, improves the fibrinolytic properties of blood, restores blood circulation, prevents the formation of new and resolves previously formed tight scars and adhesions, prevents vascular obliteration, stimulates tissue regeneration and epithelization.

Activates the function of the adrenal cortex: anti-inflammatory effect, increases the concentration of hormones in the blood. It stimulates the kinin system.

Indications

chronic liver diseases;
strictures of the urethra, ureters, chronic prostatitis, urethritis;
injuries of the central nervous system and peripheral nervous system;
tuberculosis (torpid form in the resorption phase);
uveitis, iridocyclitis, herpetic eye infection, corneal opacification;
inflammation of the uterine appendages, infertility;
adhesive disease of the abdominal cavity;
burn disease;
sexually transmitted diseases;
psoriasis and other chronic skin diseases.

For pyrotherapy.

Pharmacological effect

Pyrogenal is a broad-spectrum immunomodulator, the main ones of which are the activation of the reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. Pyrogenal has adjuvant, desensitizing and anti-inflammatory properties, increases the general and specific resistance of the body, and affects the thermoregulatory centers of the hypothalamus.

The drug, by stimulating the cells of the phagocytic system, activates phagocytosis, the secretion of oxygen radicals, the synthesis of interleukin-1 (IL-1, IL-2), tumor necrosis factor (TNF L), interferon (IFN L). Acting on fibroblasts, it prevents collagen synthesis by fibroblasts and accelerates the process of fibrocyte maturation.

Stimulates the activity of hyaluronidase: increases tissue permeability, improves the fibrinolytic properties of blood, restores blood circulation, prevents the formation of new ones and resolves previously formed dense scars and adhesions, prevents vascular obliteration, stimulates tissue regeneration and epithelization.

Activates the function of the adrenal cortex: has an anti-inflammatory effect, increases the concentration of hormones in the blood. Stimulates the kinin system.

Special instructions

If, with intramuscular administration, hyperthermia, chills, and malaise usually occur within 3-8 hours, then the dosage that caused such a reaction is repeated in the following days (usually 1-3 days) until the reaction stops, after which the dose is successively increased.

In the presence of convulsive readiness, the drug is prescribed against the background of anticonvulsant therapy.

Active ingredient

Bacterial lipopolysaccharide

Composition

1 ml of solution contains:

Active ingredient:

bacterial lipopolysaccharide for intramuscular administration;

Excipients:

phosphate buffer solution (pH = 6.7–7.3)

Pregnancy

Contraindicated during pregnancy and breastfeeding.

Contraindications

blood diseases;
pregnancy.
acute febrile illnesses;
chronic diseases in the acute and decompensation stages (with the exception of diseases that are an indication for prescribing the drug);

With caution: diseases of the cardiovascular system, kidneys, diabetes mellitus, decreased seizure threshold, seizures, febrile seizures.

Side Effects

Hyperthermia up to 37.5 °C, accompanied by mild chills and mild malaise. This condition can last from 3 to 8 hours. In this case, the dose that caused such a reaction is repeated in the following days until the reaction to its administration stops (usually 1-3 injections), after which the dose is successively increased.

In rare cases, individuals may experience severe chills, fever up to 39.5 °C, headache, and lower back pain. These reactions usually last from 6 to 8 hours, after which the temperature decreases and side effects disappear. In these cases, it is recommended to reduce the dose of the drug.

When using the drug for pyrotherapy, the above reactions are acceptable.

Interaction

The drug is compatible and goes well with all drugs used in the treatment of diseases and conditions indicated in the indications.

Enhances the effectiveness of chemotherapy drugs as part of complex therapy.

Storage conditions

In a dry place, protected from light, at a temperature of 2–10 °C

Shelf life

2 years

Manufacturer

Research Institute of EM named after Gamaleya, Russia