Polyoxidonium, vaginal and rectal suppositories 12 mg 10 pcs

Polyoxidonium, vaginal and rectal suppositories 12 mg 10 pcs

Name: Polyoxidonium, vaginal and rectal suppositories 12 mg 10 pcs
SKU: 208538
Availability: InStock

€27.65

EAN: 4607035392337 SKU: 208538 Categories: Immune system, Immunostimulants, Medicine

Description

Azoximera bromide has a complex immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory action.

The basis of the mechanism of immunomodulatory action of azoximer bromide is direct effect on phagocytic cells and natural killer cells as well as stimulation of antibody formation, synthesis of interferon-alpha and interferon-gamma.

The detoxifying and antioxidant properties of azoximer bromide are largely determined by the structure and high molecular weight nature of the drug.

Azoximera bromide increases resistance of the body against local and generalized infections of bacterial, fungal and viral etiology. It restores immunity in conditions of secondary immunodeficiency caused by various infections, injuries, complications of surgery, burns, autoimmune diseases, malignant tumors, chemotherapy drugs, cytostatics, steroid hormones.

A characteristic feature of azoximer bromide when applied topically (intranasally, sublingually) is the ability to activate the body’s early defense factors against infection: the drug stimulates the bactericidal properties of neutrophils, macrophages and increases their ability to engulf bacteria, increases the bactericidal properties of saliva and mucous secretions of the upper respiratory tract.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins and salts of heavy metals from the body, and inhibits lipid peroxidation through both interception of free radicals and elimination of catalytically active Fe²⁺ ions.

Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximera bromide is well tolerated, has no mitogenic, polyclonal activity, antigenic properties, has no allergic, mutagenic, embryotoxic, teratogenic and carcinogenic action. Azoximer bromide is odorless and tasteless, has no local irritant effect when applied to the mucous membranes of the nose and oropharynx.

Indications

Cancer, Burns, Immunodeficiency states, Bone fractures, Tuberculosis, Otitis, Urethritis, Herpes, Haymorrhoea, Prevention of flu and colds, Colds, Trophic ulcers, Cytomegalovirus infection, Prostatitis, Flu, Female genital inflammation, Pharyngitis, Fungus, Bronchial asthma, Chronic infections, Pollinosis<>.p> In adults and children over 6 years – treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology), in remission and acute stages.

To treat (in combination therapy):

Acute and exacerbation of chronic recurrent infectious-inflammatory diseases of various localization, bacterial, viral and fungal etiology;

inflammatory diseases of the urogenital tract (urethritis, cystitis, pyelonephritis, prostatitis, salpingo-oophoritis, endomiometritis, colpitis, cervicitis, cervicosis, bacterial vaginosis);

various forms of pulmonary tuberculosis;

allergic diseases (including allergic diseases of the lungs).ч. Pollinosis, bronchial asthma, atopic dermatitis) complicated by recurrent bacterial, fungal and viral infection;

Rheumatoid arthritis complicated by recurrent bacterial, fungal and viral infection, with long-term use of immunosuppressants;

For activation of regenerative processes (fractures, burns, trophic ulcers);

In oncology during and after chemo- and radiation therapy – to decrease the immunosuppressive, nephro- and hepatotoxic effects of drugs.

For prophylaxis (monotherapy):

recurrent herpetic infection of the urogenital tract;

exacerbations of chronic foci of infection;

Influenza and other acute respiratory infections in the preepidemic and epidemic period in immunocompromised persons;

secondary immunodeficiencies due to aging or exposure to adverse factors.

Active ingredient

Azoximera bromide

Composition

Composition per suppository:

The active ingredient:

azoximera bromide – 12 mg

Associates (for a dosage of 12 mg):

Mannitol – 3.6 mg;

Povidone K17 – 2.4 mg;

Cocoa butter – 1282 mg

Interaction
Interaction
Drug interactions have not been established. It is possible to use Polioxidonium^® with many drugs, including is compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, GCS, cytostatics and β-adrenomimetics.
Azoximera bromide does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6 cytochrome P450 isoenzymes; therefore the drug is compatible with antibiotics, antiviral, antifungal and antihistamine drugs, GBS and cytostatics.
If a patient is taking the above or any other medications (including over-the-counter medications), they should talk to their physician before taking Polioxidonium®.

Directions for use
Directions for use
The drug should be used only according to those indications, that method of use and in those doses that are specified in the instructions. If after treatment no improvement occurs or symptoms worsen, or new symptoms appear, it is necessary to consult a doctor.
Once a day daily, every other day or twice a week.
If necessary, it is possible to carry out repeated courses of therapy in 3-4 months. If the drug is repeatedly administered its effectiveness is not reduced.
Recommended regimen of the drug
For treatment in adults:
– rectally by 1 supoon. Once a day after cleansing the bowels;
Vaginally for gynecological diseases: 1 supoon. Once a day (at night) inserted into the vagina in the supine position.
Dosage and administration for adults
In chronic inflammatory and infectious diseases with acute conditions – suppositories 12 mg 1 time daily for 3 days and then every other day. The course of treatment – 10 suppositories;
– for acute infectious processes and to activate the regenerative processes (fractures, burns, trophic ulcers) – suppositories 12 mg 1 time daily. The course of treatment – 10 suppositories;
– with gynecological diseases – suppositories 12 mg 1 time daily for 3 days, then every other day. The course of treatment – 10 suppositories;
– with exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) – suppositories 12 mg 1 time daily. The course of treatment – 10 suppositories;
In case of pulmonary form of tuberculosis – suppositories 12 mg 1 time daily for 3 days, then every other day. The course of treatment is 20 suppositories. Then it is possible to use the maintenance therapy – suppositories 6 mg 2 times a week for a course of up to 2-3 months.
In the complex therapy of cancer diseases during chemotherapy and radiotherapy – suppositories 12 mg daily 2-3 days before the course of chemotherapy or radiotherapy. Subsequently, 12 mg 2 times a week, the course of up to 20 suppositories.
In allergic diseases complicated by an infectious syndrome, 12 mg suppositories 1 time a day. The course of treatment – 10 suppositories;
– in rheumatoid arthritis – suppositories 12 mg every other day. The course of treatment is 10 suppositories.
For prophylaxis (monotherapy):
– exacerbations of chronic foci of infection – 10 suppositories;
– influenza and acute respiratory infections – suppositories 12 mg once a day. The course – 10 sups.;
– secondary immunodeficiencies arising due to aging – suppositories 12 mg 2 times a week. The course – 10 suppositories, 2-3 times a year.
For the treatment of children and adolescents from 6 to 18 years:
In children and adolescents from 6 to 18 years, suppositories are administered rectally only, 1 suppository. 6 mg once a day after cleansing the bowels:
– with chronic inflammatory and infectious diseases in the acute stage – suppositories 6 mg once a day for 3 days, then – every other day. The course of treatment – 10 suppositories;
– for acute infectious processes and to activate the regenerative processes (fractures, burns, trophic ulcers) – suppositories 6 mg 1 time daily. The course of treatment – 10 suppositories;
– with exacerbations of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) – suppositories 6 mg once a day daily. The course of treatment – 10 suppositories;
– with pulmonary form of tuberculosis – suppositories 6 mg 1 time daily for 3 days, then every other day. The course of treatment is 20 suppositories. Further it is possible to use the maintenance therapy – suppositories 6 mg 2 times a week, the course up to 2-3 months;
In the complex therapy of oncological diseases during chemotherapy and radiotherapy – suppositories 6 mg daily 2-3 days before the course of chemotherapy or radiotherapy. Thereafter – 6 mg 2 times a week, the course of up to 20 suppositories;
– in allergic diseases complicated by an infectious syndrome – suppositories 6 mg once a day daily. Course of treatment – 10 suppositories;
– in rheumatoid arthritis – suppositories 6 mg every other day. Course of treatment – 10 suppositories.
For prophylaxis (monotherapy):
– exacerbations of chronic foci of infection, recurrent herpetic infection of the urogenital tract – suppositories 6 mg every other day. The course – 10 suppositories;
– influenza and acute respiratory infections – suppositories 6 mg once a day. The course – 10 suppositories.
With patients who received immunosuppressive therapy for a long time, cancer patients, patients who underwent radiation, patients with acquired defects of immune system (HIV), long-term from 2-3 months to one year maintenance therapy with Polioxidonium® is indicated (for adults – 12 mg, for children over 6 years – 6 mg 1-2 times a week).

Special Instructions
Special Instructions
If an allergic reaction develops, discontinue the use of the drug Polioxidonium^® and consult a physician.
If it is necessary to stop taking the drug Polioxidonium^® can be stopped immediately, without gradual reduction of the dose.
If another dose of the drug is missed, subsequent administration should be done as usual, as indicated in these instructions or as recommended by the physician. The patient should not administer a doubled dose to make up for missed doses.
Do not use the drug if there are visual signs that it is unusable (defective packaging).

Features
Features
Suppositories: when administered rectally, it has high bioavailability (at least 70%), reaching C_max in blood 1 h after administration. The half-life is about 0.5 h, the half-elimination period is 36.2 h.
In the body it is hydrolyzed to oligomers, which are excreted mainly by the kidneys. There is no cumulative effect.

Contraindications
Contraindications
hypersensitivity;
acute renal failure;
pregnancy (no clinical experience of use);
lactation;
children under 6 years of age.
With caution
Chronic renal failure (use no more than 2 times per week).

Side effects
Side effects
very rarely – local reactions in the form of redness, swelling, itching of the perianal area, vaginal itching (due to individual sensitivity to the drug components).

Overdose
Overdose
Cases of overdose of Polioxidonium^® are unknown.

Pregnancy use
Pregnancy use
Polioxidonium is contraindicated in pregnancy, lactation and children under 6 months of age (no clinical experience of use).
.

Additional information
Weight 0.024 kg
Shelf life
2 years. Do not use the drug after the expiration date stated on the package.
Conditions of storage
In a dry place protected from light at a temperature of 2 to 15 ° C. Keep out of the reach of children.
Manufacturer
NPO Petrovax Pharm, Russia
Medication form
Vaginal and rectal suppositories
Brand
NPO Petrovax Pharm