Piracetam, tablets 400 mg, 60 pcs.
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Piracetam activates associative processes in the central nervous system, improves mood, memory and mentality in sick and healthy people. It stimulates intellectual activity and integrative activity of the brain, facilitates learning processes, improves connections between hemispheres of the brain and synaptic conduction in the cortex, increases mental performance, stabilizes and restores impaired brain functions (memory, consciousness, speech). Piracetam normalizes the ratio of ADP and ATP (inhibits nucleotide phosphatase and activates adenylate cyclase), increases phospholipase A activity, stimulates bioenergetic and plastic processes in nervous tissue, and accelerates neurotransmitter exchange.
Piracetam increases resistance of brain tissue to toxic influences and hypoxia, increases the synthesis of phospholipids and nuclear RNA, and increases glycolytic processes and glucose utilization in the brain. Piracetam blocks platelet aggregation, improves microcirculation, optimizes the ability of red blood cells to pass through microvessels and the conformational properties of the red blood cell membrane, increases regional blood flow in ischemic brain areas. Piracetam increases EEG beta and alpha activity and decreases delta activity. It reduces vestibular nystagmus. During hypoxia, intoxication, trauma, electroconvulsive effect has a neuroprotective effect.
In connection with antihypoxic action piracetam is effective in complex treatment of myocardial infarction. Anxiolytic and sedative effects of piracetam are absent.
Piracetam is almost completely and quickly absorbed after oral administration. Bioavailability is 100%. When oral administration of 2 g of the drug the maximum concentration in plasma is 40-60 mcg/ml after 30 minutes. Piracetam does not bind to plasma proteins. After 2-8 hours the maximum concentration in the cerebrospinal fluid is reached. Piracetam penetrates all tissues and organs, penetrates through the placental barrier. It is almost not metabolized. It accumulates selectively in cerebral cortex, mainly in parietal, frontal and occipital lobes, basal ganglia and cerebellum. Half-life of piracetam from plasma is 4-5 hours; from cerebrospinal fluid it is 6-8 hours. More than 95% of the drug is excreted unchanged by the kidneys after 30 hours. The elimination half-life is longer in patients with renal insufficiency.
Indications
Learning disabilities, Stroke sequelae, Attention and memory impairment, Alzheimer’s disease, Hangover, Acquired dementia, Concussion and other brain injuries, Disorientation, Headache, Alcoholism, Nausea, Tinnitus, Dizziness
- Chronic cerebrovascular insufficiency (hypertension, atherosclerosis, vascular parkinsonism), which is accompanied by impaired attention, memory, speech, headache and dizziness;
- ischemic stroke and its consequences;
- psychorganic disorders;
- dementia (senile dementia, Alzheimer’s disease, vascular dementia);
- cranial trauma;
- intoxication (recovery period, comatose and subcomatose states);
- diseases of the nervous system, which are accompanied by a decrease in the level of awakeness, intellectual and mental functions, behavioral and emotional-volitional disorders;
- dizziness;
- vestibular nystagmus;
- painful-apathetic state;
- aphasia;
- Epilepsy (as an adjuvant);
- senile and atrophic processes;
- depressive conditions that are resistant to antidepressant treatment;
- Prevention or elimination of neurological, somatovegetative, psychiatric complications of neuroleptic and other psychotropic drugs treatment;
- neurotic depression with prevalence in the clinical picture of senesto-psychondriacal and asthenic disorders, adynamia, ideomotor retardation phenomena
- .Psycho-organic syndrome in chronic alcoholism;
- curing the pre- and delirium, withdrawal states in drug addiction and alcoholism;
- acute intoxication with morphine, ethanol, amphetamine, barbiturates;
- children – cerebral palsyIn children – cerebral palsy, consequences of perinatal damage of the central nervous system, mental retardation, learning disability in psychoorganic syndrome, speech disorder, oligophrenia, memory impairment, cerebristia, intellectual failure;
- Severine cell anemia (as a part of complex treatment).
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Active ingredient
Piracetam
Composition
Active substance:
Piracetam – 400 mg.
Excipients (core):
croscarmellose sodium, pregelatinized starch, povidone (polyvinylpyrrolidone), magnesium stearate.
Excipients (coating):
hypromellose, macrogol, titanium dioxide.
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How to take, the dosage
Ingestion.
With meals or on an empty stomach with fluids.
Symptomatic treatment of psychoorganic syndrome: 2.4 – 4.8 g per day in 2-3 doses.
The treatment of vertigo and related balance disorder: 2.4 to 4.8 g per day in 2 to 3 doses.
The treatment of cortical myoclonias: it is started with a dose of 7.2 g per day, every 3-4 days the dose is increased by 4.8 g per day until the maximum dose of 24 g per day in 2 -3 doses. Treatment is continued for the entire period of the disease. Every 6 months an attempt should be made to reduce the dose or to cancel the drug, gradually reducing the dose by 1.2 g per day every 2 days.
The treatment of sickle cell anemia: The daily prophylactic dose is 160 mg/kg body weight divided into 4 equal doses.
The treatment of dyslexia in children (in combination with other treatments): the recommended daily dose for children from 8 years and adolescents is 3.2 g divided into 2 doses.
Interaction
Piracetam increases the effects of indirect anticoagulants, psychostimulants, central effects of thyroid hormones (anxiety, tremor, sleep disturbance, irritability, confusion of consciousness). The severity of extrapyramidal disorders is increased when combined use of piracetam with neuroleptics.
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Special Instructions
With caution, use in patients with significant hemostasis disorder, major surgery and severe bleeding; with renal insufficiency. Continuous monitoring of renal function parameters is recommended. In case of occurrence of sleep disturbances it is recommended to cancel evening intake of piracetam and join this dose to the daytime intake.
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Contraindications
Hypersensitivity (including to pyrrolidone derivatives), marked renal insufficiency (with creatinine clearance less than 20 ml/min), hemorrhagic stroke, Huntington’s disease, agitated depression, breastfeeding, pregnancy, age less than 1 year.
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Side effects
Nervous system and senses: hyperkinesia, somnolence, increased irritability, depression, agitation, asthenia, aggressive behavior, dizziness, sleep disturbance, headache, tremor, increased sexuality;
Digestive system: Nausea, diarrhea, vomiting, abdominal pain;
Metabolism: weight gain;
Circulatory system: exacerbation of coronary artery disease, arterial hypertension or hypotension;
Skin: hypersensitivity reactions.
Overdose
In case of overdose with piracetam side effects increase.
Treatment: gastric lavage, activated charcoal, symptomatic treatment; there is no specific antidote, hemodialysis is possible (effectiveness is 50-60%).
Pregnancy use
Taking piracetam is contraindicated during pregnancy.
Breastfeeding should be stopped during therapy with piracetam because the drug penetrates into the breast milk.
Similarities
Nootropil, Piracetam, Piracetam bufus, Notrocetam
Weight | 0.043 kg |
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Shelf life | 3 years |
Conditions of storage | In a dry, light-protected place at a temperature not exceeding 25 °C |
Manufacturer | Ozon, Russia |
Medication form | pills |
Brand | Ozon |
Other forms…
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