Papazole, tablets 30 mg+30 mg 20 pcs

Name: Papazole, tablets 30 mg+30 mg 20 pcs
SKU: 251448
Availability: InStock

€3.52

EAN: 4601669009142 SKU: 251448 Categories: Medicine, Pain and fever, Pain and spasms

Description

Combination drug, has antispasmodic, hypotensive, vasodilatory effects. Bendazol is an antispasmodic agent of myotropic action; it has hypotensive, vasodilatory effects, stimulates spinal cord function, has moderate immunostimulatory activity.

Papaverine is an antispasmodic agent and has hypotensive effect. It inhibits phosphodiesterase, causes accumulation of cAMP and decrease of calcium in cells, tones down and relaxes smooth muscles of internal organs (gastrointestinal, respiratory and urogenital systems) and blood vessels.

In high doses it reduces excitability of the heart muscle and slows intracardiac conduction. Action on CNS is weak (in high doses it has sedative effect).

Indications

Biliary dyskinesia, Gallstone disease, Colitis, Colitis, Blood pressure, Urinary stone disease, Renal colic, Hypertension (high blood pressure)

– Arterial hypertension (labile);

– spasm of peripheral arteries and cerebral vessels;

– spasm of the smooth muscles of internal organs (including.

– gastric and duodenal ulcer, pylorus spasm, colic, cholecystitis, spastic colitis);

– poliomyelitis (residual effects);

– peripheral paralysis of facial nerve.

Active ingredient

Bendazol, Papaverine

Composition

Active substances:

bendazole hydrochloride (dibazole) – 30 mg,

papaverine hydrochloride – 30 mg;

excipients:

potato starch – 56 mg,

talc – 3 mg,

stearic acid – 1 mg,

talc,

stearic acid – 1 mg.

How to take, the dosage
How to take, the dosage
At the mouth, adults – 1-2 tablets 2-3 times a day.
The course of treatment is individual, usually 2-4 weeks.
In children – as prescribed by the doctor.

Interaction
Interaction
Pharmacodynamic: with simultaneous use with antispasmodics, sedatives, diuretics (dichlothiazide, diacarb, furosemide, spironolactone, etc.), tricyclic antidepressants, novokainamide, reserpine, quinidine sulfate may increase the hypotensive effect.
Weakens the effect of anticholinesterase drugs (galantamine, proserine, physostigmine, etc.) on smooth muscle; reduces the antiparkinsonian effect of levodopa.
When Papazole and nitrofurantoin are used in combination, hepatitis may develop. Pharmacokinetic: adsorbents, astringents and coating agents reduce absorption of the drug in the gastrointestinal tract.

Special Instructions
Special Instructions
Alcohol intake should be avoided during treatment.
The drug should be prescribed with caution and in small doses in elderly and frail patients, as well as patients with craniocerebral trauma, liver and kidney function disorders, hypothyroidism, insufficiency of adrenal function, prostate hypertrophy.

Contraindications
Contraindications
– AV conduction disorders;
– epilepsy syndrome;
– bronchoobstructive syndrome;
– childhood under 3 years;
– hypersensitivity to the components of the drug.
With caution is administered in reduced intestinal peristalsis, brain injury, hepatic and/or renal insufficiency, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, pregnancy and lactation.

Side effects
Side effects
Digestive system disorders: nausea, constipation.
CNS disorders: dizziness.
Cardiovascular system: AV-blockade, arrhythmias, decreased myocardial contractility.
Other: allergic reactions, increased sweating.

Overdose
Overdose
Papazole overdose symptoms are a combination of symptoms of papaverine and bendazole overdose.
Symptoms of papaverine overdose: diplopia weakness drowsiness lethargy.
Symptoms of bendazole overdose: arterial hypotension decreased tissue perfusion arrhythmia headache weakness.
Treatment: gastric lavage activated charcoal.

Pregnancy use
Pregnancy use
The safety of the drug in pregnancy and lactation has not been established.
Hence, the use of the drug during pregnancy is possible only when the expected benefits to the mother exceed the potential risk to the fetus.

Additional information
Weight 0.010 kg
Shelf life
5 years
Conditions of storage
Store at a temperature not exceeding 25C.
Manufacturer
Pharmstandard-Leksredstva, Russia
Medication form
pills
Brand
Pharmstandard-Leksredstva