Combination drug, has antispasmodic, hypotensive, arteriodilatory action.
Bendazole is an antispasmodic agent of myotropic action; it has hypotensive, vasodilatory effects, stimulates spinal cord function, has moderate immunostimulatory activity.
Papaverine hydrochloride is an antispasmodic agent and has hypotensive effect. It inhibits FDE, causes accumulation of Ca2+, reduces tone and relaxes smooth muscles of internal organs (gastrointestinal, respiratory and urogenital systems) and blood vessels.
In high doses it reduces excitability of the heart muscle and slows intracardiac conduction. Action on CNS is weak (in high doses it has sedative effect).
Colic, Hypertension (high blood pressure), Colitis, Renal colic, Cholecystitis, Gastric and 12 duodenal ulcer
Arterial hypertension (labile), spasm of peripheral arteries and cerebral vessels, spasm of smooth muscles of internal organs (incl.including gastric and duodenal ulcer, pylorus spasm, intestinal colic, cholecystitis, spastic colitis), poliomyelitis (residual effects), peripheral paralysis of the facial nerve.
1 tablet contains:
bendazol hydrochloride (dibazole) – 30 mg,
papaverine hydrochloride – 30 mg;
Potato starch – 56 mg,
talc – 3 mg,
stearic acid – 1 mg,
stearic acid – 1 mg.
How to take, the dosage
At the mouth, 1-2 tablets 2-3 times a day for adults.
In concomitant use of the drug with antispasmodics, sedatives, diuretics, tricyclic antidepressants, procainamide, reserpine, quinidine the severity of the hypotensive effect may be increased.
Papazole attenuates the effect of anticholinesterase drugs on smooth muscles (galantamine, proserine, physiostigmine).
Adsorbents, astringent and enveloping drugs reduce absorption of the drug in the gastrointestinal tract.
Papazole is used with caution in patients with decreased bowel tone and cardiac conduction disorders.
The intake of alcohol should be avoided during treatment.
Hypersensitivity, AV conduction disorders, epileptic syndrome, bronchoobstructive syndrome, children under 3 years of age.
Decreased intestinal peristalsis, CMT, hepatic and/or renal insufficiency, hypothyroidism, adrenal insufficiency, prostatic hypertrophy; pregnancy, lactation.
Digestive system disorders: nausea, constipation.
CNS disorders: dizziness.
Cardiovascular system: AV-blockade, arrhythmias, decreased myocardial contractility.
Others: allergic reactions, increased sweating.
It is contraindicated in children under 1 year of age.
Prescribes with caution during pregnancy and lactation.
|Conditions of storage|
Store at a temperature not exceeding 25C.
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