Papazole, tablets 30 mg+30 mg 10 pcs

Combination drug, has antispasmodic, hypotensive, arteriodilatory action.

Bendazole is an antispasmodic agent of myotropic action; it has hypotensive, vasodilatory effects, stimulates spinal cord function, has moderate immunostimulatory activity.

Papaverine hydrochloride is an antispasmodic agent and has hypotensive effect. It inhibits FDE, causes accumulation of Ca2+, reduces tone and relaxes smooth muscles of internal organs (gastrointestinal, respiratory and urogenital systems) and blood vessels.

In high doses it reduces excitability of the heart muscle and slows intracardiac conduction. Action on CNS is weak (in high doses it has sedative effect).

Indications

Arterial hypertension (labile), spasm of peripheral arteries and cerebral vessels, spasm of smooth muscles of internal organs (including gastric and duodenal ulcers, pyloric spasm, intestinal colic, cholecystitis, spastic colitis), poliomyelitis (residual effects), peripheral paralysis of the facial nerve.

Pharmacological effect

The combined drug has antispasmodic, hypotensive, arteriodilatory effects.

Bendazole is an antispasmodic agent with myotropic action; has a hypotensive, vasodilating effect, stimulates the function of the spinal cord, and has moderate immunostimulating activity.

Papaverine hydrochloride is an antispasmodic and has a hypotensive effect. Inhibits PDE, causes the accumulation of cAMP in the cell and a decrease in Ca2+ content, reduces the tone and relaxes the smooth muscles of internal organs (gastrointestinal tract, respiratory and genitourinary systems) and blood vessels.

In large doses, it reduces the excitability of the heart muscle and slows down intracardiac conduction. The effect on the central nervous system is weak (in large doses it has a sedative effect).

Special instructions

Papazole is prescribed with caution to patients with decreased intestinal tone and cardiac conduction disorders.

During the treatment period, alcohol intake should be avoided.

Active ingredient

Bendazole, Papaverine

Composition

1 tablet contains:

Active substances:

bendazole hydrochloride (dibazole) – 30 mg,

papaverine hydrochloride – 30 mg;

Excipients:

potato starch – 56 mg,

talc – 3 mg,

stearic acid – 1 mg,

talc,

stearic acid – 1 mg.

Pregnancy

Contraindicated in children under 1 year of age.

Prescribe with caution during pregnancy and lactation.

Contraindications

Hypersensitivity, AV conduction disorders, epileptic syndrome, broncho-obstructive syndrome, children under 3 years of age.

With caution

Reduced intestinal motility, head injury, liver and/or kidney failure, hypothyroidism, adrenal insufficiency, prostate hypertrophy; pregnancy, lactation period.

Side Effects

From the digestive system: nausea, constipation.

From the side of the central nervous system: dizziness.

From the cardiovascular system: AV blockade, arrhythmias, decreased myocardial contractility.

Other: allergic reactions, increased sweating.

Interaction

With simultaneous use of the drug with antispasmodics, sedatives, diuretics, tricyclic antidepressants, procainamide, reserpine, quinidine, the severity of the hypotensive effect may be enhanced.

Papazole weakens the effect of anticholinesterase drugs on smooth muscle (galantamine, proserine, physiostigmine).

Adsorbents, astringents and enveloping drugs reduce the absorption of the drug in the gastrointestinal tract.

Storage conditions

Store at a temperature not exceeding 25C.

Shelf life

5 years

Manufacturer

Pharmstandard-Leksredstva, Russia