Ondansetron, 2 mg/ml 2 ml 5 pcs

Ondansetron is an antiemetic.

Ondansetron effectively prevents and eliminates nausea and vomiting occurring against the background of anti-tumor chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron to selectively block the serotonin 5-HT3 receptors.

It is believed that stimulation of afferent fibers of vagus nerve by serotonin released from enterochromaffin cells of gastrointestinal mucosa plays an important role in the occurrence of nausea and vomiting during antitumor therapy. By blocking 5-HT3-receptors, ondansetron prevents the occurrence of the gag reflex.

In addition ondansetron inhibits central links of the gag reflex by blocking 5-HT3-receptors of the floor of the IV ventricle (area postrema).

Indications

Prevention of nausea and vomiting during antitumor chemotherapy or radiation therapy; prevention and treatment of nausea and vomiting in the postoperative period.

Active ingredient

Composition

1 ampoule contains:

Active substance:

ondansetron (in the form of dihydrate hydrochloride) 2 mg.

How to take, the dosage

The drug Ondansetron is prescribed 8-32 mg per day, in the form of tablets, syrup, suppositories, or injections. The dose and method of administration are chosen individually.

Special Instructions

It is not recommended to inject in the same syringe with other drugs.

Injection forms are diluted only with the recommended solutions. It is compatible with infusion solutions of sodium and potassium chloride, dextrose, mannitol, Ringer.

Before they are administered, make sure that there are no large particles and color changes (if the container allows); precipitate contained on the walls of the ampoule (has no effect on activity and safety) is dissolved by vigorous shaking; ampoules are not autoclaved, protected from exposure to light.

Contraindications

Pregnancy I trimester, hypersensitivity to ondansetron.

Side effects

Gastrointestinal system disorders: constipation/diarrhea, dry mouth, hiccups, transient increase in AST and ALT levels.

Nervous system and sensory organs: headache, dizziness, spontaneous motor disorders and seizures, visual acuity disorders, extrapyramidal disorders (in parenteral use).

Cardiovascular and blood (hematopoiesis, hemostasis): syncope, chest pain, in some cases with ST-segment depression, bradycardia, arrhythmia, arterial hypotension.

Allergic reactions: urticaria, bronchospasm, laryngospasm, angioedema, anaphylaxis.

Others: fever, sensation of heat, blood rush to the face, hypokalemia, hypercreatinemia, local reactions (pain, redness and burning at the injection site); burning in the anus and rectum (suppositories).

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