Nystatin, ointment 100000 units/g 30 g

Nystatin is a polyene antifungal antibiotic that is highly active against yeast-like fungi of the genus Candida. It has a fungicidal effect.

The antibiotic has a large number of double bonds in its structure with high affinity to sterol structures of the cytoplasmic membrane of fungi, which promotes incorporation of the drug molecule into the cell membrane and formation of numerous channels through which uncontrolled transport of electrolytes occurs.

Elevated osmolarity inside the cell leads to cell death.

Indications

Candidiasis of the mucous membranes (including the vagina, rectum and lower intestines), skin and internal organs; prevention of candidiasis during long-term treatment with antibacterial agents, especially in depleted and weakened patients.

Pharmacological effect

Nystatin is a polyene antifungal antibiotic, highly active against yeast-like fungi of the genus Candida. Has a fungicidal effect.

The structure of the antibiotic contains a large number of double bonds, which have a high tropism for the sterol structures of the cytoplasmic membrane of fungi, which facilitates the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which uncontrolled transport of electrolytes occurs.

An increase in osmolarity inside the cell leads to its death.

Special instructions

The use of ointment can be combined with oral nystatin.

Active ingredient

Nystatin

Composition

Active ingredient:

nystatin 100,000 units;

Excipients:

lanolin anhydrous;

medical Vaseline.

Contraindications

Hypersensitivity, liver dysfunction, pancreatitis, gastric and duodenal ulcers, pregnancy.

Side Effects

Skin itching, rashes, fever, chills and allergic reactions are possible.

Interaction

With simultaneous use of nystatin with clotrimazole, the activity of the latter decreases.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 5 °C

Shelf life

3 years

Manufacturer

Biosynthesis, Russia