Novocaine, rectal 100 mg 10 pcs

Pharmacotherapeutic group: Local anesthetic agent

ATC code: N01BA

Pharmacodynamics:

Local anesthetic agent with moderate anesthetic activity and a wide range of therapeutic action. Being a weak base it blocks sodium channels, prevents generation of impulses in the endings of sensitive nerves and conduction of impulses along the nerve fibers. It changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses conduction of not only pain but also other modality impulses.

Indications

Active ingredient

Composition

1 suppository contains:

active ingredient:

procaine hydrochloride (novocaine) 100 mg;

excipients: suppository bases: solid fat (vitepsol, supposir) – enough to obtain a suppository weight of 1.25 g.

How to take, the dosage

Rectally.

Pre-release the suppository from the contour cell pack and insert it deep into the anus (after a purging enema or spontaneous bowel cleansing) 1-2 times a day.

Interaction

Topical anesthetics increase the central nervous system depressant effect of other drugs.

Anticoagulants (ardeparin dalteparin danaparoid enoxaparin heparin warfarin) increase the risk of bleeding.

The use with monoamine oxidase inhibitors (furazolidone procarbazine selegiline) increases the risk of hypotension.

The effects of myorelaxant medications are enhanced and prolonged.

Vasoconstrictors (epinephrine methoxamine phenylephrine) prolong the local anesthetic effect.

Procaine reduces antimiasthenic effects of medications especially when used in high doses, which requires additional correction of myasthenia gravis treatment.

Cholinesterase inhibitors (antimyasthenic drugs cyclophosphamide demecarine ecothiophate thiotepa) decrease the metabolism of local anesthetic drugs.

The metabolite of procaine (para-aminobenzoic acid) is an antagonist of sulfonamides.

Contraindications

Hypersensitivity (including to para-aminobenzoic acid and other local anesthetic esters).

Childhood (under 12 years) in elderly patients (over 65 years) pregnancy lactation.

Side effects

Overdose

Symptoms: pallor of skin and mucous membranes dizziness nausea vomiting “cold” sweat increased breathing tachycardia decreased blood pressure up to collapse apnoea methemoglobinemia. Effects on the central nervous system are manifested by feelings of fear, hallucinations, convulsions, motor agitation.

Treatment: maintenance of adequate pulmonary ventilation with oxygen inhalation intravenous administration of short-acting drugs for general anesthesia in severe cases – detoxification and symptomatic therapy.

Similarities