Naftoderil, cream 1% 15 g

Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol, a component of the cell wall of the fungus.

It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).

Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi naphthifin shows fungicidal or fungistatic activity depending on the strain of the microorganism.

It has antibacterial activity against Gram-positive and Gram-negative microorganisms that may cause secondary bacterial infections. It has anti-inflammatory activity, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When applied topically, naphthifin penetrates the skin well, creating sustained antifungal concentrations in its various layers. After application on the skin, less than 6% of naphthifin is absorbed systemically. The absorbed amount is partially metabolized and excreted by the kidneys and through the intestine. The half-life of naphthifin is 2-3 days.

Indications

• Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis);
• finger mycoses (tinea manum, tinea pedum);
• fungal nail infections (onychomycoses);
• dermatomycoses;
• different (peptica) tetter;
• dermatomycoses (with or without associated itching).

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Active ingredient

Naftifin

Composition

Active ingredient:

How to take, the dosage

Externally.

In case of skin lesions
Naftoderil drug is applied once a day on the affected skin surface and adjacent areas (approximately 1 cm of healthy skin area at the edges of the affected area) after their thorough cleaning and drying.

The therapy duration in case of dermatomycosis is 2-4 weeks (up to 8 weeks if necessary), in case of candidiasis – 4 weeks.
When the nails are affected

The drug Naftoderil is applied twice a day on the affected nail. Before the first use of the drug, remove the affected part of the nail with scissors or a nail file as much as possible.
Duration of therapy for onychomycosis is up to 6 months.

To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.

If there is no improvement after treatment, or if symptoms worsen, or new symptoms develop, you should consult a physician. Use only in the amount and according to the directions.

Interaction

Interaction with other drugs has not been studied.

Special Instructions

The drug Naftoderil is not intended for use in ophthalmology. The drug should not be allowed to get into the eyes.
A course of treatment is required to achieve therapeutic effect.