Naftifin is an antifungal agent for external use belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-23-epoxidase, which leads to reduction of formation of ergosterol which is a part of the cell wall of the fungus.
Active against dermatophytes such as Trichophyton Epidermophyton Microsporum mold fungi (Aspergillus spp.) yeast fungi (Candida spp. Pityrosporum) and other fungi (such as Sporothrix schenckii).
Against dermatophytes and aspergillus naphthifin acts fungicidal.
In yeast fungi naphthifin has fungicidal or fungistatic activity depending on the strain of the microorganism.
It has antibacterial activity against Gram-positive and Gram-negative microorganisms that may cause secondary bacterial infections.
It has anti-inflammatory activity which helps to quickly disappear the symptoms of inflammation, especially itching.
When applied topically, naphthifin penetrates the skin well, creating sustained antifungal concentrations in its various layers, making once-daily use possible.
– Fungal infections of the skin and skin folds (tinea corporis tinea inquinalis);
– interfinger mycoses (tinea manum tinea pedum);
– fungal infections of the nails (onychomycosis);
– skin candidiasis;
– variegated (peptic ulcer);
– dermatomycoses (with or without associated itching).
The drug Naftoderil is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis and also in areas of hair growth.
1 ml of the solution contains:
The active ingredient: naphthyphine hydrochloride – 10 mg.
Auxiliary substances: propylene glycol – 50 mg, ethanol (ethyl alcohol) 95% – 400 mg, purified water – up to 1.0 ml.
How to take, the dosage
In case of skin lesions
The drug Naftoderil is applied once a day on the affected skin surface and adjacent areas (approximately 1 cm of healthy skin around the edges of the affected area) after they have been thoroughly cleaned and dried.
The duration of therapy in dermatomycosis is 2-4 weeks (up to 8 weeks if necessary); in candidiasis it is 4 weeks.
In case of nail lesions
The drug Naftoderil is applied 2 times a day to the affected nail. Before the first use, remove the affected part of the nail with a pair of scissors or a nail file as much as possible.
The duration of therapy for onychomycosis is up to 6 months.
To prevent recurrence, treatment should be continued for at least 2 weeks after clinical symptoms have disappeared.
If there is no improvement after treatment, or if symptoms worsen or new symptoms develop, a doctor should be consulted. Use only in the manner and in the dosage indicated. If necessary, please consult a physician before using the product.
Interaction with other drugs has not been studied.
The drug Naftoderil is not intended for use in ophthalmology. The drug should not be allowed to get into the eyes.
Course treatment is required to achieve a therapeutic effect.
The propylene glycol in the solution can irritate the skin; if you experience any side effects, stop using and see a physician.
Effects on the ability to drive vehicles and other activities requiring concentration and quick psychomotor reaction.
– Hypersensitivity to naphthyphine or other components of the drug;
– pregnancy and breastfeeding (safety and efficacy of use have not been established).
– application on the wound surface.
Childhood (experience with clinical use is limited).
In some cases there may be local reactions: dry skin, skin hyperemia (redness) and burning. The side effects are reversible and do not require discontinuation of treatment.
If any of the side effects listed in the instructions worsen or if any other side effects not listed in the instructions are noted, you should tell your doctor immediately.
If the drug is used in accordance with the instructions for use, overdose is unlikely.
In case of accidental ingestion, gastric lavage and symptomatic therapy are indicated.
The drug is contraindicated during pregnancy and breastfeeding (safety and efficacy of naphthifin in this category of patients has not been studied).
Exoderil, Mycoderil, Mizol, Naftoderil, Naftifin, Fungoderil
3 years. Do not use after the expiration date.
|Conditions of storage|
At a temperature not exceeding 25 ° C. Store out of the reach of children.
Kirov Pharmaceutical Factory, Russia
solution for external use
Kirov Pharmaceutical Factory
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