Naftoderil, cream 1% 30 g

Naftifine is an antifungal agent for external use belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol, which is a part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, mold fungi (Aspergillus spp.), yeast fungi (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi naphthifin has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics
When applied externally, naphthifin penetrates the skin well, creating sustained antifungal concentrations in its various layers. After application on the skin less than 6% of naphthifin is absorbed systemically. The absorbed amount is partially metabolized and excreted by the kidneys and through the intestine. The half-life of naphthifin is 2-3 days.

Indications

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Active ingredient

Naftifin

How to take, the dosage

Outdoors
Naftoderil drug is applied once a day to the affected skin surface and adjacent areas (about 1 cm of healthy skin at the edges of the affected area) after thoroughly cleaning and drying them.
Duration of therapy in case of dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks), in case of candidiasis – 4 weeks.
Affected nails
The drug Naftoderil is applied twice a day on the affected nail. Before the first use of the drug the affected part of the nail is removed with a pair of scissors or a nail file.
Duration of therapy for onychomycosis – up to 6 months.
To prevent relapse the treatment should be continued for at least 2 weeks after the clinical symptoms are gone.

If after treatment there is no improvement or if symptoms worsen or new symptoms develop, you should consult a doctor. Use only in the amount and according to the directions.

Special Instructions

The drug Naftoderil is not intended for use in ophthalmology. Avoid contact of the drug with the eyes.
A course of treatment is required to achieve therapeutic effect.

Influence on ability to drive vehicles, mechanisms

The drug Naftoderil has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.

Contraindications

• high sensitivity to naphthyphine, benzyl alcohol or other ingredients of the drug
• pregnancy and breastfeeding (safety and efficacy of use have not been established).

Cautions

Childhood (clinical experience limited).

Side effects

In some cases there may be local reactions: dry skin, skin hyperemia (redness) and burning. The side effects are reversible and do not require discontinuation of treatment.

If any of the side effects listed in the instructions worsen, or if you experience any other side effects not listed in the instructions, you should tell your doctor right away.

Overdose

When using the drug in accordance with the instructions for use, overdose is unlikely. In case of accidental ingestion gastric lavage, symptomatic therapy is indicated.

Similarities

Exoderil, Mycoderil, Mizol, Naftoderil, Naftifin, Fungoderil