Naftoderil, cream 1% 15 g

Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol, a component of the cell wall of the fungus.

It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).

Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi naphthifin shows fungicidal or fungistatic activity depending on the strain of the microorganism.

It has antibacterial activity against Gram-positive and Gram-negative microorganisms that may cause secondary bacterial infections. It has anti-inflammatory activity, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When applied topically, naphthifin penetrates the skin well, creating sustained antifungal concentrations in its various layers. After application on the skin, less than 6% of naphthifin is absorbed systemically. The absorbed amount is partially metabolized and excreted by the kidneys and through the intestine. The half-life of naphthifin is 2-3 days.

Indications

Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis);
interdigital mycoses (tinea manum, tinea pedum);
fungal nail infections (onychomycosis);
skin candidiasis;
versicolor (pityriasis versicolor);
ringworm (with or without accompanying itching).

Pharmacological effect

Pharmacodynamics
Naftifine is an antifungal agent for external use, belonging to the class of allylamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus.

Active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (for example, Sporothrix schenckii).

Naftifine has a fungicidal effect against dermatophytes and aspergillus. In relation to yeast fungi, naftifine exhibits fungicidal or fungistatic activity depending on the strain of the microorganism.

It has antibacterial activity against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections. It has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When used externally, naftifine penetrates well into the skin, creating stable antifungal concentrations in its various layers. After application to the skin, less than 6% of naftifine is subject to systemic absorption. The absorbed amount is partially metabolized and excreted by the kidneys and intestines. The half-life of naftifine is 2-3 days.

Special instructions

The drug Naftoderil is not intended for use in ophthalmology. The drug should not come into contact with the eyes.
To achieve a therapeutic effect, a course of treatment is required.

Impact on the ability to drive vehicles and machinery

Active ingredient

Naftifin

Composition

Active ingredient:

Pregnancy

Use of the drug during pregnancy and breastfeeding
feeding is contraindicated (safety and effectiveness of naftifine in
this category of patients has not been studied).

Contraindications

Hypersensitivity to naftifine, benzyl alcohol or other components of the drug;
pregnancy and breastfeeding (safety and effectiveness of use have not been established).
With caution

Children’s age (experience of clinical use is limited).

Side Effects

In some cases, local reactions may be observed: dry skin, skin hyperemia (redness) and burning. Side effects are reversible and do not require discontinuation of treatment.

If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Interaction

Interaction with other drugs has not been studied.

Overdose

When using the drug in accordance with the instructions for use
overdose is unlikely. In case of accidental ingestion, it is indicated
gastric lavage, symptomatic therapy.

Storage conditions

At a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

3 years.

Manufacturer

Ozon, Russia