Naftoderil, 1% 20 ml

Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, mold fungi (Aspergillus spp.), yeast fungi (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).

With respect to dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi naphthifin shows fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When applied topically, naphthifin penetrates the skin well, creating sustained antifungal concentrations in its various layers. After application on the skin, less than 6% of naphthifin is absorbed systemically. The absorbed amount is partially metabolized and excreted by the kidneys and through the intestine. The half-life of naphthifin is 2-3 days.

Indications

– Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis);

– interfinger mycoses (tinea manum, tinea pedum);

– fungal nail infections (onychomycosis);

– skin candidiasis;

– variegated (peptic ulcer);

– dermatomycoses (with or without associated itching).

The drug Naftoderil is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis as well as in areas of hair growth.

Active ingredient

Composition

Composition per 100 g:

Active substance:

Naphthyphine hydrochloride – 1.00 g.

Auxiliary substances:

cetostearyl alcohol, 8.00 g;

isopropyl myristate, 8.00 g;

polysorbate-60, 6.10 g;

cetyl palmitate, 2.00 g;

sorbitan stearate – 1.90 g;

benzyl alcohol – 1.00 g;

sodium hydroxide – 0.12 g;

purified water – up to 100.00 g.

How to take, the dosage

Externally.

In case of skin lesions

The drug Naftoderil is applied once a day on the affected skin surface and adjacent areas (about 1 cm of healthy skin at the edges of the affected area) after they have been thoroughly cleaned and dried.

The duration of therapy in dermatomycosis is 2-4 weeks (up to 8 weeks if necessary); in candidiasis it is 4 weeks.

In case of nail lesions

The drug Naftoderil is applied 2 times a day to the affected nail. Before the first use, remove the affected part of the nail with a pair of scissors or a nail file as much as possible.

The duration of therapy for onychomycosis is up to 6 months.

To prevent recurrence, treatment should be continued for at least 2 weeks after clinical symptoms have disappeared.

If symptoms do not improve or worsen after treatment, or if new symptoms develop, consult a physician. Use the drug only according to the route of administration and in the doses mentioned in the instructions. If necessary, please consult a physician before using the drug.

Interaction

Special Instructions

The drug Naftoderil is not intended for use in ophthalmology. The drug should not be allowed to get into the eyes.

Course treatment is required to achieve a therapeutic effect.

The propylene glycol in the solution may irritate the skin; if any side effects occur, discontinue use and see a physician.

The drug Naftoderil has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.

Synopsis

Contraindications

– pregnancy and breastfeeding (safety and efficacy of use have not been established).

– application on the wound surface.

Childhood (experience with clinical use is limited).

Side effects

In some cases there may be local reactions: dry skin, skin hyperemia (redness) and burning. The side effects are reversible and do not require discontinuation of treatment.

If any of the side effects listed in the instructions worsen, or if you experience any other side effects not listed in the instructions, you should tell your doctor right away.

Overdose

If the drug is used in accordance with the instructions for use, overdose is unlikely.

In case of accidental ingestion gastric lavage, symptomatic therapy is indicated.

Similarities