Naftoderil, 1% 10 ml

Pharmacotherapeutic group

Antifungal agent

ATX code

D01AE22

Pharmacodynamics:

Naftifin is an antifungal agent for external use belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-23-epoxidase, which leads to reduction of formation of ergosterol which is a part of the cell wall of the fungus.

Active against dermatophytes such as Trichophyton Epidermophyton Microsporum mold fungi (Aspergillus spp.) yeast fungi (Candida spp. Pityrosporum) and other fungi (such as Sporothrix schenckii).

Against dermatophytes and aspergillus naphthifin acts fungicidal.

In yeast fungi naphthifin has fungicidal or fungistatic activity depending on the strain of the microorganism.

It has antibacterial activity against Gram-positive and Gram-negative microorganisms that may cause secondary bacterial infections.

It has anti-inflammatory activity which helps to quickly disappear the symptoms of inflammation, especially itching.

Pharmacokinetics:

When applied topically, naphthifin penetrates the skin well, creating sustained antifungal concentrations in its various layers, making once-daily use possible.