Mycoderil, cream 1% 30 g
€21.93 €18.27
Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol, which is a part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).
With respect to dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When applied topically, it penetrates well into various layers of the skin, creating stable antifungal concentrations in its various layers. After application on the skin less than 6% of naphthifin is absorbed systemically. Absorbed amount is partially metabolized and excreted by kidneys and intestine. Half-life period of the drug is 2 – 3 days.
Indications
— Fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
— interdigital mycoses (tinea manum, tinea pedum);
– fungal nail infections (onychomycosis);
— skin candidiasis;
– pityriasis versicolor;
– ringworm (with or without itching).
Pharmacological effect
Pharmacodynamics
Naftifine is an antifungal agent for external use, belonging to the class of allylamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (for example, Sporothrix schenckii).
Naftifine has a fungicidal effect against dermatophytes and aspergillus. Against yeast fungi, the drug exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections. It has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When used externally, it penetrates well into various layers of the skin, creating stable antifungal concentrations in its various layers. After application to the skin, less than 6% of naftifine is subject to systemic absorption. The absorbed amount is partially metabolized and excreted by the kidneys and intestines. The half-life of the drug is 2 – 3 days.
Special instructions
According to the instructions, Mikoderil is not intended for use in ophthalmology.
Active ingredient
Naftifin
Composition
1 g cream: active substance:
naftifine hydrochloride – 10 mg;
additional components:
isopropyl myristate – 80 mg,
cetostearyl alcohol – 80 mg,
polysorbate 60 – 61 mg,
cetyl palmitate – 20 mg,
sorbitan stearate – 19 mg,
benzyl alcohol – 10 mg,
sodium hydroxide – 1.2 mg,
purified water – up to 1000 mg.
Pregnancy
The safety profile of naftifine when used during pregnancy and lactation has not been studied, therefore Mikoderil is contraindicated for women during these periods of life.
Contraindications
– Hypersensitivity to naftifine, benzyl alcohol or other components of the drug;
– pregnancy and lactation (the safety and effectiveness of the drug in this category of patients have not been studied).
With caution: children’s age (experience of clinical use is limited).
Side Effects
Reactions at the application site may occur: dry skin, skin flushing and burning.
Interaction
No interaction of Mikoderil with its simultaneous use with other drugs has been noted.
Storage conditions
Storage temperature no more than 25 °C.
Shelf life
2 years if you follow the manufacturer’s recommendations
Manufacturer
Lecco CJSC, Russia
Shelf life | 2 years if the manufacturer's recommendation is followed |
---|---|
Conditions of storage | Storage temperature not more than 25 ° C.. |
Manufacturer | Lekko ZAO, Russia |
Medication form | exterior cream |
Brand | Lekko ZAO |
Other forms…
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