Mycoderil, 1% 30 ml
€34.58 €28.81
Pharmacotherapeutic group: antifungal agent.
The ATX code: D01AE22
Pharmacological properties
Pharmacodynamics
Mycoderil®, topical solution, 1% is an antifungal agent for external use, belonging to allilamines class. Its active ingredient is naphthifine. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candida spp., Pityrosporum), molds (Aspergillus) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. Naftifin has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.
Naftifine has anti-inflammatory properties that help to quickly disappear the symptoms of inflammation, especially itching.
Pharmacokinetics
When used topically, naphthifin quickly penetrates the skin, creating sustained antifungal concentrations in different layers of the skin, making once-daily use possible.
Indications
fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
interdigital mycoses (tinea manum, tinea pedum);
fungal nail infections (onychomycosis);
skin candidiasis;
pityriasis versicolor;
inflammatory dermatomycosis (with or without itching).
Pharmacological effect
Pharmacotherapeutic group: antifungal agent.
ATX code: D01AE22
PHARMACOLOGICAL PROPERTIES
Pharmacodynamics
Mikoderil®, solution for external use, 1% is an antifungal agent intended for external use, belonging to the class of allylamines. Its active ingredient is naftifine. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, while affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candida spp., Pityrosporum), molds (Aspergillus) and other fungi (for example Sporothrix schenckii). Naftifine has a fungicidal effect against dermatophytes and aspergillus. Against yeast fungi, the drug exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. Naftifine has antibacterial activity against gram-positive and gram-negative microorganisms that cause secondary bacterial infections.
Naftifine has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When used externally, naftifine quickly penetrates the skin, creating stable antifungal concentrations in its various layers, which makes it possible to use it once a day.
Special instructions
Mikoderil®, solution for external use, 1% is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.
A course of treatment is required.
Avoid contact of the drug with eyes and open wounds.
Use in pediatrics
The drug should be used with caution in children.
INFLUENCE ON THE ABILITY TO DRIVE VEHICLES AND OTHER MECHANISMS
Mikoderil®, solution for external use, 1% has no negative effect
influence on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.
Active ingredient
Naftifin
Composition
COMPOSITION PER 1 ML:
Pregnancy
The use of the drug during pregnancy and lactation is not recommended (the safety and effectiveness of the drug in this category of patients has not been studied).
Contraindications
Hypersensitivity to naftifine or propylene glycol; pregnancy and lactation (the safety and effectiveness of the drug in this category of patients have not been studied).
Application of the drug to the wound surface is contraindicated.
WITH CAUTION
Children’s age (experience of clinical use is limited).
Side Effects
In some cases, local reactions may be observed: dry skin, skin hyperemia and burning.
Side effects are reversible and do not require discontinuation of treatment.
If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.
Storage conditions
Store at a temperature not exceeding 25 oC. Keep out of the reach of children.
Shelf life
2 years. Do not use after the expiration date stated on the package.
Manufacturer
Pharmstandard-Leksredstva, Russia
Shelf life | 2 years. Do not use after the expiration date printed on the package. |
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Conditions of storage | Store at a temperature not exceeding 25 oC. Keep out of reach of children. |
Manufacturer | Pharmstandard-Leksredstva, Russia |
Medication form | solution for external use |
Brand | Pharmstandard-Leksredstva |
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