Mycoderil, 1% 20 ml
€27.40 €22.83
Mycoderil® is an antifungal drug for external use, the active ingredient of which is naphthifine. Naphtifine is an antifungal agent belonging to the class of alilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candidaspp., Pityrosporum), molds (Aspergillus) and other fungi (such as Srohichryshepensis). Against dermatophytes and aspergillus naphthifin acts fungicidal.
In yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. Naphtifine has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.
Naftifine has anti-inflammatory properties that help to quickly disappear the symptoms of inflammation, especially itching.
Pharmacokinetics
When used topically, naphthifin quickly penetrates the skin, creating sustained antifungal concentrations in different layers of the skin, making once-daily use possible.
Indications
Fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
interdigital mycoses (tinea manum, tinea pedum);
fungal nail infections (onychomycosis);
skin candidiasis;
pityriasis versicolor;
inflammatory dermatomycosis (with or without itching).
Pharmacological effect
Mikoderil® is an antifungal drug for external use, the active ingredient of which is naftifine. Naftifine is an antifungal agent belonging to the class of allylamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, while affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candidaspp., Pityrosporum), molds (Aspergillus) and other fungi (for example Sporothrixschenckii). Naftifine has a fungicidal effect against dermatophytes and aspergillus.
Against yeast fungi, the drug exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. Naftifine has antibacterial activity against gram-positive and gram-negative microorganisms that cause secondary bacterial infections.
Naftifine has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When used externally, naftifine quickly penetrates the skin, creating stable antifungal concentrations in its various layers, which makes it possible to use it once a day.
Special instructions
Read the instructions for use carefully before you start using this medication as they contain information that is important to you.
Save the instructions, you may need them again.
If you have any questions, consult your doctor.
The medicine you are being treated with is intended for you personally and should not be used by others because it may cause harm to them even if they have the same symptoms as you.
Mikoderil®, spray for external use, 1% is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.
Course treatment required.
Avoid contact of the drug with eyes and open wounds.
Use in pediatrics
The drug should be used with caution in children.
Impact on the ability to drive vehicles and machinery
Mikoderil®, spray for external use, 1% does not have a negative effect on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.
Active ingredient
Naftifin
Composition
Active ingredient:
naftifine hydrochloride – 10.0 mg.
Excipients:
propylene glycol – 50.0 mg,
ethanol (ethyl alcohol 95%) – 400.0 mg,
purified water – up to 1 ml.
Pregnancy
The use of the drug during pregnancy and breastfeeding is contraindicated (the safety and effectiveness of the drug in this category of patients has not been studied).
Contraindications
Hypersensitivity to naftifine or propylene glycol; pregnancy and breastfeeding (the safety and effectiveness of the drug in this category of patients have not been studied).
Application of the drug to the wound surface is contraindicated.
With caution
Side Effects
In some cases, local reactions may be observed: dry skin, skin hyperemia and burning. Side effects are reversible and do not require discontinuation of treatment. If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.
Interaction
Interactions with other drugs have not been studied.
Overdose
No cases of overdose have been reported.
Storage conditions
At a temperature not exceeding 25 °C in the original packaging (bottle in a cardboard box).
Keep out of the reach of children.
Shelf life
2 years.
Manufacturer
Pharmstandard-Leksredstva, Russia
Shelf life | 2 years. |
---|---|
Conditions of storage | At a temperature not exceeding 25 ° C in the original packaging (bottle in carton pack). Keep out of reach of children. |
Manufacturer | Pharmstandard-Leksredstva, Russia |
Medication form | solution for external use |
Brand | Pharmstandard-Leksredstva |
Other forms…
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