Lyoton 1000, gel 1000 me/g 30 g

Pharmacotherapeutic group:direct acting anticoagulant for topical use

ATX code: C05BA03

Pharmacological properties

Pharmacodynamics< br>Sodium heparin is a direct acting anticoagulant. It prevents thrombosis, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood.

When applied topically it has local antithrombotic, anti-edematous and anti-inflammatory effect, improves blood microcirculation and activates tissue exchange which accelerates the process of hematoma and thrombus resorption, reduces tissue edema.

Pharmacokinetics< br> A small amount of heparin is absorbed from the skin surface into the systemic blood stream. The maximum concentration of the drug in the blood is observed 8 hours after application. Excretion of heparin mainly occurs through the kidneys, the half-life is 12 hours. It does not penetrate through the placental barrier.

Indications

diseases of the superficial veins: varicose veins, chronic venous insufficiency and related complications (superficial thrombophlebitis, superficial periphlebitis);
blunt injuries and soft tissue bruises;
subcutaneous hematomas, including hematomas after venous surgery, phlebectomy;
localized infiltrates and swelling of soft tissues.

Pharmacological effect

Pharmacotherapeutic group: direct-acting anticoagulant for topical use

ATH CODE: C05BA03

Pharmacological properties

Pharmacodynamics
Heparin sodium is a direct anticoagulant. Prevents thrombus formation, inhibits the activity of hyaluronidase, and activates the fibrinolytic properties of blood.

When applied externally, it has a local antithrombotic, anti-edematous and anti-inflammatory effect, improves blood microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots and reducing tissue swelling.

Pharmacokinetics
A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the drug in the blood is observed 8 hours after application. Heparin is eliminated primarily through the kidneys, with a half-life of 12 hours. Does not penetrate the placental barrier.

Special instructions

It is not recommended to apply to mucous membranes, open wounds and use in the presence of purulent lesions at the intended site of application of the gel.

It is not recommended to use Lyoton® 1000 for deep vein thrombosis. Methyl parahydroxybenzoate and propyl parahydroxybenzoate included in the drug Lyoton® 1000 can cause allergic reactions (including delayed ones).

Impact on the ability to drive vehicles and machinery
The use of the drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Heparin sodium

Composition

For 100 g of gel:

Active ingredient: sodium heparin – 100,000 IU

Excipients: carbomer, methyl parahydroxybenzoate, propyl parahydroxybenzoate, ethanol 96%, neroli oil, lavender oil, trolamine (triethanolamine), purified water.

Pregnancy

The use of Lyoton® 1000 is possible during pregnancy and breastfeeding if the expected benefit to the mother outweighs the potential risk to the fetus and child.
Heparin does not penetrate the placental barrier and into breast milk. Due to the insignificant absorption of heparin when applied externally, the drug does not have a systemic effect on the body. However, before using Lyoton® 1000 during pregnancy and breastfeeding, you should consult your doctor.

Contraindications

hypersensitivity to heparin or other components of the drug;
violation of the integrity of the skin at the site of application of the drug (ulcerative-necrotic changes in the skin); traumatic violations of the integrity of the skin (open wounds);
increased tendency to bleeding, thrombocytopenia;
age under 18 years (the safety and effectiveness of the drug have not been studied).

Side Effects

In very rare cases (< 1/10000), when used externally, hypersensitivity reactions to heparin are possible. In some cases (frequency unknown: cannot be estimated from the available data), allergic reactions to the components of the drug may occur, manifested by redness of the skin and/or itching, which usually disappear after stopping use of the drug. If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

With long-term use of heparin on large areas of the skin and simultaneous use of indirect anticoagulants (warfarin, acenocoumarol, etc.), prothrombin time and blood clotting time should be monitored.

It is not recommended to mix with other products for external use. Concomitant use with drugs for external use containing tetracyclines, antihistamines or non-steroidal anti-inflammatory drugs is not recommended. If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Lyoton® 1000.

Overdose

To date, no cases of overdose have been reported.
In case of overdose, the effect of heparin can be neutralized by administering a solution of protamine sulfate.

Storage conditions

At a temperature not exceeding 25 °C.
Keep out of the reach of children!

Shelf life

5 years. Do not use after expiration date.

Organization receiving complaints from consumers:

LLC “Berlin-Chemie/A. Menarini”, Russia

123112, Moscow, Presnenskaya embankment, building 10, Business Center “Tower on the Embankment”, Block B, tel. (495) 785-01-00, fax (495) 785-01-01.

Manufacturer

A. Menarini Manufacturing Logistics and Services S, Italy