Lidocaine, 20 mg/ml 2 ml 10 pcs
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Lidocaine is a short-acting local anesthetic of the amide type. Its mechanism of action is based on reducing the permeability of the neuronal membrane to sodium ions. As a result, the rate of depolarization decreases and the excitation threshold increases, leading to reversible local numbness. Lidocaine is used to achieve conductive anesthesia in various parts of the body and to control arrhythmias. It has a rapid onset of action (about one minute after intravenous injection and fifteen minutes after intramuscular injection) and spreads quickly to surrounding tissues. Its action lasts 10-20 minutes and about 60-90 minutes after intravenous and intramuscular injection, respectively.
Local and regional anesthesia, conductive anesthesia for large and small interventions.
How to take, the dosage
The dosing regimen should be chosen based on the patient’s response at the site of administration. The drug should be administered at the lowest concentration and dose that gives the desired effect. The maximum dose for adults should not exceed 300 mg.
Lidocaine toxicity is increased when used concomitantly with cimetidine and propranololol due to increased lidocaine concentration; this requires reduction of lidocaine dose. Both drugs reduce hepatic blood flow. In addition, cimetidine inhibits microsomal activity. Ranitidine slightly decreases lidocaine clearance, which leads to an increase in its blood concentration.
Lidocaine should be administered by specialists with experience and equipment for resuscitation. If local anesthetics are administered, resuscitation equipment should be available. It should be used with caution in patients with myasthenia gravis, epilepsy, chronic heart failure, bradycardia and respiratory depression, and in combination with drugs that interact with lidocaine and lead to increased bioavailability, potentiation of its effects (e.g. phenytoin) or prolonged excretion (e.g. in hepatic or terminal renal failure, where lidocaine metabolites may cumulate).
Hypersensitivity to amide type anesthetics. Atrioventricular (AV) block of the 3rd degree. Hypovolemia.
Chronic heart failure II class, arterial hypotension, hypovolemia, atrioventricular block of degree I, sinus bradycardia, severe hepatic and/or renal failure, severe myasthenia gravis, epileptiform convulsions (including anamnesis).anamnesis), reduced hepatic blood flow, weakened or elderly patients (over 65 years), children under 18 years of age (due to delayed metabolism the drug may accumulate).
Adverse reactions are described according to MedDRA system-organ classes.
Lidocaine, Versatis, Lidocaine-Vial
|Conditions of storage|
At a temperature not exceeding 25°C. Keep out of reach of children.
Pharmasintez JSC, Russia
solution for injection
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