Lidocaine, 20 mg/ml 2 ml pcs

How to take, the dosage

For local conduction anesthesia the usual dose is 5 ml to 10 ml of Lidocaine 2% solution. For brachial and sacral plexus anesthesia 5-10 ml of 2% solution is administered. For anesthesia of the fingers and toes, 2 ml to 3 ml of 2% solution is administered. The maximum dose of Lidocaine 2% solution is 10 ml, and this dose should not be administered again within 24 hours. In local anesthesia the drug should be injected into highly vascularized tissues with caution to avoid its entry into the bloodstream. Before administering Lidocaine in high doses, administration of barbiturates is recommended.

When used in cardiology, the single dose is 1-2 mg/kg body weight and can be up to a maximum of 100 mg. This dose may be repeated every 3 to 4 minutes up to a total dose of 300 mg.

Intravenous drip is administered at a dose of 20-55 mcg/kg/min, but no more than 2 mg/min in isotonic solution or Ringer’s solution. IV drip infusion is used only after a jet infusion. The duration of IV drip administration is 24-36 hours.

I/m is administered in a dose of 2-4 mg/kg of body weight into the gluteal or deltoid muscle at intervals of 4 h to 6 h. The single dose should not exceed 200 mg.

In myocardial infarction, before transporting the patient to the hospital, Lidocaine is administered 4 mg/kg in a single prophylactic dose (200 to 300 mg maximum) in a m/m dose.

Interaction

It is undesirable to combine lidocaine with the following drugs:
With beta-adrenoblockers because of increased toxic properties of lidocaine, with digitoxin because of weakened cardiotonic effect, with curare-like drugs – increased muscle relaxation.

Lidocaine should not be administered together with aymalin, amiodarone, verapamil or quinidine due to increased cardiodepressant effect.
Concomitant use of lidocaine and novocainamide may cause CNS agitation and hallucinations.

In intravenous administration of hexenal or thiopental sodium with lidocaine may cause respiratory depression.

MoA inhibitors may increase the local anesthetic effect of lidocaine. Patients taking MAO inhibitors should not administer lidocaine parenterally.

The simultaneous administration of lidocaine and polymyxin-B may increase the inhibitory effect on neuromuscular transmission, so the respiratory function of the patient should be monitored in this case.

The simultaneous use of lidocaine with hypnotics or sedatives may increase their CNS depressant effect. When lidocaine is administered intravenously to patients taking cimetidine such unwanted effects as stunned state, somnolence, bradycardia, parasthesias and others are possible. This is associated with increased plasma levels of lidocaine, which is explained by the release of lidocaine from bonding with blood proteins, as well as a slowdown of its inactivation in the liver. If combination therapy with these drugs is necessary, the dose of lidocaine should be reduced.

Pharmaceutical interaction
When used concomitantly, the following drugs increase the concentration of lidocaine in blood serum: aminazin, cimetidine, propranolol, pethidine, bupivacaine, quinidine, disopyramide, amitriptyline, imipramine, nortriptyline.

Special Instructions

With caution is used in patients with liver dysfunction, circulatory insufficiency, arterial hypotension, renal failure, epilepsy. In these cases, reduction of the dose of the drug is required.

In rapid intravenous administration there may be a sharp decrease in blood pressure and development of collapse.

In these cases, mesaton, ephedrine and other vasoconstrictors are used. Care should be used when administering lidocaine solutions into highly vascularized tissue to avoid entrapment in the lumen (e.g., neck during thyroid surgery) (Lower doses of lidocaine are indicated in these cases).

Particular caution should be exercised when mucosal trauma is present, when there is mental retardation, and in very old and/or debilitated patients who are already receiving lidocaine-type medications for cardiac problems.

In dentistry and orthopedics, the drug should only be used with elastic blinders.
Ingestion or contact with the eyes should be avoided and it is important to prevent the aerosol from entering the respiratory tract (risk of aspiration). Application of the drug to the back of the throat requires special care. Remember that Lidocaine suppresses the pharyngeal reflex and inhibits the cough reflex, which can lead to aspiration and bronchopneumonia.

Pediatric use
Keep in mind that children have a much more frequent swallowing reflex than adults.
Lidocaine in aerosol form is not recommended for local anesthesia before tonsillectomy and adenotomy in children under 8 years of age.

Influence on driving and operating machinery
If the side effects after using the drug do not cause discomfort, there are no restrictions on driving and operating machinery.

Contraindications

• Sinus node weakness syndrome.
• Developed bradycardia.
• Antrioventricular block of degree 2 and 3 (except when a ventricular simulation probe is inserted).
• Cardiogenic shock.
• Myasthenia gravis.
• High individual sensitivity to lidocaine.
• A history of lidocaine-induced epileptiform seizures.
• Developed impairment of liver function.

When plaster is used in dentistry as an impression material, aerosol is contraindicated because of the risk of aspiration.

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Side effects

• headache
• dizziness
• numbness of the tongue and oral mucosa
• reduction of blood pressure
• reduction of heart rate

.slowed heart rate

• a burning sensation when the aerosol hits the anesthetized surface (stops a few seconds after the onset of anesthesia).

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Overdose

Symptoms: CNS symptoms (including seizures) and cardiovascular symptoms are possible.

Treatment: in case of CNS and cardiovascular system symptoms it is necessary to make sure that the airway is clear, to provide fresh air, oxygen and/or artificial respiration.

In case of convulsions 50-100 mg of ditilin and/or 5-15 mg of diazepam should be administered as soon as possible, barbituric acid derivatives (sodium thiopental) may be used. Dialysis is ineffective in the acute phase of lidocaine overdose.

In case of bradycardia, cardiac conduction abnormalities, atropine 0.5-1 mg IV may be administered.

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Similarities

Lidocaine, Versatis, Lidocaine-Vial