Lidocaine, 20 mg/ml 2 ml 10 pcs

Lidocaine is a short-acting local anesthetic of the amide type. Its mechanism of action is based on reducing the permeability of the neuronal membrane to sodium ions. As a result, the rate of depolarization decreases and the excitation threshold increases, leading to reversible local numbness. Lidocaine is used to achieve conductive anesthesia in various parts of the body and to control arrhythmias. It has a rapid onset of action (about one minute after intravenous injection and fifteen minutes after intramuscular injection) and spreads quickly to surrounding tissues. Its action lasts 10-20 minutes and about 60-90 minutes after intravenous and intramuscular injection, respectively.

Indications

Local and regional anesthesia, conduction anesthesia for major and minor interventions.

Pharmacological effect

Lidocaine is a short-acting amide-type local anesthetic. Its mechanism of action is based on a decrease in the permeability of the neuron membrane to sodium ions. As a result, the rate of depolarization decreases and the excitation threshold increases, leading to reversible local numbness. Lidocaine is used to achieve conduction anesthesia in various parts of the body and control arrhythmia. It has a rapid onset of action (about one minute after intravenous administration and fifteen minutes after intramuscular administration), and quickly spreads into surrounding tissues. The action lasts 10-20 minutes and about 60-90 minutes after intravenous and intramuscular administration, respectively.

Special instructions

The administration of lidocaine should be carried out by specialists with experience and equipment for resuscitation. When local anesthetics are administered, resuscitation equipment must be available. It should be used with caution in patients with myasthenia gravis, epilepsy, chronic heart failure, bradycardia and respiratory depression, as well as in combination with drugs that interact with lidocaine and lead to increased bioavailability, potentiation of effects (for example, phenytoin) or prolongation of elimination (for example, in hepatic or end-stage renal failure, in which metabolites may accumulate lidocaine).

Active ingredient

Lidocaine

Composition

Active substances per 1 ml:

Pregnancy

Fertility

Contraindications

Hypersensitivity to amide-type anesthetics. Atrioventricular (AV) block 3rd degree. Hypovolemia.
Chronic heart failure FC II, arterial hypotension, hypovolemia, atrioventricular block I degree, sinus bradycardia, severe hepatic and/or renal failure, myasthenia gravis, epileptiform convulsions (including in history), reduced hepatic blood flow, debilitated or elderly patients (over 65 years of age), children under 18 years of age (due to slow metabolism, accumulation of the drug is possible).

Side Effects

Adverse reactions are described according to MedDRA system organ classes.

Interaction

The toxicity of lidocaine increases when it is used simultaneously with cimetidine and propranolol due to an increase in the concentration of lidocaine; this requires a reduction in the dose of lidocaine. Both drugs reduce hepatic blood flow. In addition, cimetidine inhibits microsomal activity. Ranitidine slightly reduces the clearance of lidocaine, which leads to an increase in its concentration in the blood.

Overdose

Symptoms

Storage conditions

At a temperature not higher than 25°C. Keep out of the reach of children.

Manufacturer

Pharmasintez JSC, Russia