Immunofan, spray 45 mcg/dose 40 doses

Imunofan – detoxifying, hepatoprotective, antioxidant, immunomodulatory.

Pharmacodynamics

The drug has immune-regulating, detoxifying, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. It corrects the state of the immune system, restores the balance of oxidation-antioxidant reactions of the body and promotes overcoming of multiple drug resistance of tumor cells, mediated by proteins of the cell transmembrane transport pump.

The action of the drug starts within 2-3 hours (fast phase) and lasts up to 4 months (middle and slow phases).

In toxic and infectious liver damage the drug prevents cytolysis, reduces transaminase activity and serum bilirubin level.

In the middle phase (begins after 2-3 days, duration – up to 7-10 days) there is an increase of phagocytosis reactions and death of intracellular bacteria and viruses.

In the slow phase (starts after 7-10 days, duration – up to 4 months) the immunoregulatory action of Immunofan® ^{– restoration of disturbed parameters of cellular and humoral immunity – is observed. During this period the normalization of immunoregulatory index is observed, the increase of production of specific antibodies is noted.}

The effect of the drug on the production of specific antiviral and antibacterial antibodies is equivalent to the action of therapeutic vaccines. Unlike the latter the preparation has no significant influence on production of reactive antibodies of IgE class and does not increase immediate hypersensitivity reaction; Immunophan ^® stimulates production of IgA in case of its congenital insufficiency.

Imunophan^® effectively suppresses multiple drug resistance of tumor cells and increases their sensitivity to the action of chemotherapeutic agents.

Indications

• Adults and children over 2 years (prevention and treatment):
• immunodeficiency and toxic conditions
• acute and chronic inflammatory diseases.

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Active ingredient

Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine

How to take, the dosage

Intranasal. When using, the bottle should be held vertically with the atomizer up.

1. Remove the protective cap from the nebulizer.
2. Fill the metering pump before first use by pressing the wide rim of the nebulizer 3-4 times.
3. Push the nebulizer up into the nasal passage with the head vertical.
4. Press the wide tip of the nebulizer one time until it stops. The daily dose should not exceed 200 mcg.
   • In complex therapy of acute and chronic infectious and inflammatory diseases accompanied by symptoms of intoxication and immunodeficiency

     Apply 1 dose (50 mcg) in each nasal passage 2 times a day for 10-15 days.

   • For opportunistic infections (cytomegalovirus and herpes infections, toxoplasmosis, chlamydia, pneumocystis, cryptosporidiosis)

     1 dose (50 mcg) into each nasal passage 2 times a day, daily, the course of treatment – 10-15 days. If necessary, it is possible to repeat the course in 2-4 weeks.

   • In chronic viral hepatitis and chronic brucellosis

     One dose (50 mcg) in each nasal passage once a day, daily, course of treatment 10-15 days, to prevent relapse should be repeated in 4-6 months.

   • In the treatment regimen for patients with HIV infection

     One dose (50 mcg) in each nasal passage once a day, daily, for 10-15 days. If necessary, it is possible to repeat the course in 2-4 weeks.

   • Treatment of cancer patients in the regimen of radical combined treatment (chemo-radiation therapy and surgery

     Please 1 dose (50 mcg) in each nasal passage once a day, daily, for 8-10 days before chemo-radiation therapy and surgery with’ subsequent continuation of course for the duration of treatment.

   • In patients with advanced tumor process (stage III-IV) of different localization in terms of complex or symptomatic therapy

     In 1 dose (50 mcg) in each nasal passage once a day, daily, for 8-10 days. If necessary and in the presence of pronounced phenomena of toxicity, it is recommended to repeat the course.

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Interaction

It increases the effectiveness of other types of drug therapy: the use of immunophan helps to overcome resistance to glucocorticosteroid therapy.

The drug may be prescribed in combination with anti-inflammatory steroids and nonsteroidal anti-inflammatory drugs.

Special Instructions

As a result of activation of phagocytosis, short-term exacerbation of foci of chronic inflammation maintained due to persistence of viral or bacterial antigens is possible.

Contraindications

Hypersensitivity; children under 2 years of age.

Side effects

Possible: individual intolerance, allergic reactions.

Pregnancy use

Because of the lack of study, caution should be exercised during pregnancy and lactation.