Immunofan, rectal 90 mcg 5 pcs

Imunofan – detoxifying, hepatoprotective, antioxidant, immunomodulatory.

Pharmacodynamics

The drug has immune-regulating, detoxifying, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. It corrects the state of the immune system, restores the balance of oxidation-antioxidant reactions of the body and promotes overcoming of multiple drug resistance of tumor cells, mediated by proteins of the cell transmembrane transport pump.

The action of the drug starts within 2-3 hours (fast phase) and lasts up to 4 months (middle and slow phases).

In the middle phase (begins after 2-3 days, duration – up to 7-10 days) there is an increase of phagocytosis reactions and death of intracellular bacteria and viruses.

In the slow phase (starts after 7-10 days, duration – up to 4 months) the immunoregulatory action of Imunofan® manifests itself – restoration of disturbed indices of cellular and humoral immunity. During this period, normalization of immunoregulatory index is observed, increased production of specific antibodies is noted. Influence of the drug on production of specific antiviral and antibacterial antibodies is equivalent to the action of therapeutic vaccines. Unlike the latter the preparation does not influence significantly on production of reactive antibodies of IgE class and does not strengthen reaction of immediate hypersensitivity type; Immunofan® stimulates production of IgA at its congenital insufficiency.

Inmunophan® effectively suppresses multiple drug resistance of tumor cells and increases their sensitivity to the action of chemotherapeutic agents.

Indications

Active ingredient

Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine

Composition

Suppositories for rectal use1 sup.immunofan100 mcg

excipients:

purified water;

glycine;

solid fat;

tween 80

How to take, the dosage

Rectally. The single dose and daily dose is 100 mcg (0.1 mg) 1 suppository.

• In the treatment of cancer patients in the scheme of radical combined treatment (chemo-radiation therapy and surgery)

  Once, daily, treatment course of 8 – 10 suppositories before chemo-radiation therapy and surgery with subsequent continuation of the course for the duration of treatment.

• In patients with advanced tumor process (III – IV stages) with various localizations as a combination or symptomatic therapy

  Once daily, 8 – 10 suppositories, with 15-20 days interval of treatment and the courses repeated for the period of subsequent treatment.

• In children with malignant diseases of hematopoietic and lymphoid tissue

  Once a day, daily, treatment course of 10-20 suppositories. The drug should be administered during the whole course of chemotherapy and after the course is over to prevent toxemia.

• In the complex therapy of children with papillomatosis of the larynx and oropharynx

  once a day, daily, treatment course of 10 suppositories.

• Infections with opportunistic infections (cytomegalovirus and herpes infections, toxoplasmosis, chlamydia, pneumocystis, cryptosporidiosis)

  Once a day, daily, treatment course 15 – 20 suppositories.

• In the treatment of HIV infection

  once a day, daily, treatment course 15 – 20 suppositories. If necessary, repeat courses in 2-4 weeks.

• In chronic viral hepatitis and chronic brucellosis

  Once a day, daily, treatment course 15 – 20 suppositories, to prevent relapse should be repeated in 2 – 3 months.

• In diphtheria

  once a day, daily, treatment course of 8 – 10 suppositories. In diphtheria bacteriocarriers – once in 3 days – 3-5 suppositories.

• In the treatment of III-IV degree burns with toxemia, septic toxemia, surgical patients with septic endocarditis, nonhealing extremity wounds, purulent-septic complications.

• Once a day, daily, the course of treatment 7 – 10 suppositories, if necessary, the drug should be continued up to 20 suppositories.

• In bronchoobstructive syndrome, cholecystopancreatitis, rheumatoid arthritis

  1 time every 3 days, the course of treatment 8 – 10 suppositories, if necessary the course should be continued to 20 suppositories at the same interval.

• In the treatment of psoriasis

  once a day, daily, the course of treatment 15 – 20 suppositories.

• In adults in the vaccine prophylaxis scheme

  Once on the day of vaccination.

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Interaction

It increases the effectiveness of other types of drug therapy: the use of immunophan helps to overcome resistance to glucocorticosteroid therapy.

The drug can be prescribed in combination with anti-inflammatory steroid and nonsteroidal anti-inflammatory drugs.

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Special Instructions

As a result of activation of phagocytosis, short-term exacerbation of foci of chronic inflammation maintained due to persistence of viral or bacterial antigens is possible.

Contraindications

Hypersensitivity; children under 2 years of age.

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Side effects

Possible: individual intolerance, allergic reactions.

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Pregnancy use

Due to insufficient research, caution should be exercised during pregnancy and lactation.