Holitilin, 250 mg/ml 4 ml 3 pcs

Holitiline is a nootropic drug. It is a central cholinostimulant containing 40.5% metabolically protected choline.

It provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in CNS, activates reticular formation.

It increases linear velocity of blood flow, normalizes spatiotemporal characteristics of spontaneous bioelectrical activity of the brain, regresses focal neurological symptoms and restores consciousness; it positively affects cognitive and behavioral reactions of patients with cerebral vascular diseases (discirculatory encephalopathy and residual effects of circulatory disorders of the brain).

It has preventive and corrective effect on pathogenetic factors of involutional psychorganic syndrome, reduces cholinergic activity.

Stimulates the dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes. It has no effect on the reproductive cycle and has no teratogenic, mutagenic action.

Pharmacokinetics

Dissolution: Choline alphoscerate easily penetrates the blood-brain barrier. It is excreted mainly by the lungs as carbon dioxide (85%) and also by the kidneys and through the intestines (15%).

Indications

In complex therapy for:

traumatic brain injury with a predominantly brainstem level of damage (acute period);
cerebrovascular insufficiency;
psychoorganic syndrome against the background of degenerative diseases and involutional processes of the brain;
multi-infarct dementia.

Pharmacological effect

Holitylin is a nootropic drug. Central anticholinergic stimulant, which contains 40.5% metabolically protected choline.

Provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation.

Increases the linear speed of blood flow, promotes normalization of the spatiotemporal characteristics of spontaneous bioelectrical activity of the brain, regression of focal neurological symptoms and restoration of consciousness; has a positive effect on the cognitive and behavioral reactions of patients with vascular diseases of the brain (dyscirculatory encephalopathy and residual effects of cerebrovascular accident).

It has a preventive and corrective effect on the pathogenetic factors of involutional psychoorganic syndrome, reduces cholinergic activity.

Stimulates the dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission and plasticity of neuronal membranes. Does not affect the reproductive cycle and does not have a teratogenic or mutagenic effect.

Pharmacokinetics

Solution: Choline alfoscerate easily penetrates the blood-brain barrier. It is excreted primarily by the lungs in the form of carbon dioxide (85%), as well as by the kidneys and intestines (15%).

Special instructions

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Choline alphoscerate

Composition

1 ml. solution for intravenous and intramuscular administration contains:

active ingredient:

choline alfoscerate polyhydrate (Lipoid GPC 85F) 250 mg;

excipients:

povidone,

water for injections

Contraindications

hypersensitivity;
hemorrhagic stroke (acute stage);
pregnancy;
breastfeeding period;
age up to 18 years.

Side Effects

From the digestive system: constipation, diarrhea, dry oral mucosa, pharyngitis.

From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, dizziness.

From the skin: rash, urticaria.

Other: pain at the injection site, increased urination.

Interaction

No drug interactions have been established.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 ° C.

Shelf life

2 years.

Manufacturer

Deco Company, Russia