Holitilin, 400 mg capsules 14 pcs

Notropic remedy. Central cholinostimulant containing 40.5% of metabolically protected choline.

It provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates reticular formation. Increases the linear velocity of blood flow, promotes normalization of spatiotemporal characteristics of spontaneous bioelectrical activity of the brain, regress of focal neurological symptoms and restoration of consciousness; has a positive effect on cognitive and behavioral reactions of patients with cerebral vascular diseases (discirculatory encephalopathy and residual effects of cerebral circulatory disorders).

It has a preventive and corrective effect on pathogenetic factors of involutional psychoorganic syndrome, reduces cholinergic activity. Stimulates dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission and plasticity of neuronal membranes. It has no effect on the reproductive cycle and has no teratogenic, mutagenic action.

Pharmacokinetics

Absorption is 88%. Easily penetrates through the blood-brain barrier (when administered orally, the concentration in the brain is 45% of that in plasma). It is excreted mainly by lungs as carbon dioxide (85%) and also by the kidneys and intestines (15%).

Indications

Consequences of stroke, Acquired dementia, Alzheimer’s disease, Mental disorders, Attention and memory disorders, Impaired cerebral circulation, Headache, Aggressiveness and conflict

In complex therapy for:

• Cerebral trauma with predominantly trunk level lesions (acute period);
• Cerebrovascular insufficiency;Psychoorganic syndrome on the background of degenerative diseases and involutionary processes of the brain;
• Multi-infarct dementia.

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Active ingredient

Choline alphoscerate

Composition

1 capsule contains:
Active substance:
Choline alphosphoscerate hydrate (Glycerylphosphorylcholine hydrate), in terms of choline alphoscerate (L-a-glycerophosphorylcholine) 400 mg.
Supplements:
Purified water;
Macrogol (polyethylene glycol 400);
Povidone (Plasdon C-15 or Collidon® 17 PF).
Composition of soft gelatin capsule:
Delatin;
Glycerol (glycerol);
Methylparaben (methyl parahydroxybenzoate);
Propylparaben (propyl parahydroxybenzoate);
Sorbitol (sorbitol);
Titanium dioxide;
Iron oxide yellow dye;
Iron oxide red dye;
Iron oxide black dye;
Purified water.

How to take, the dosage

Internal, 0.4 g 3 times a day, for 3-6 months.

In the subacute period of craniocerebral trauma 0.8 g in the morning and 0.4 g during the day for 6 months.

Interaction

Drug interactions of the drug have not been established.

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Special Instructions

When treating, caution should be exercised when driving motor vehicles and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

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Contraindications

• Hypersensitivity;

• Hemorrhagic stroke (acute stage);

• Pregnancy and lactation;

• Children under 18 years of age.

Side effects

Digestive system disorders:gastritis, peptic ulcer, pharyngitis.

Nervous system disorders: nervousness, cerebral ischemia, seizures, hyperkinesia, dizziness.

Other:allergic reactions, increased frequency of urination.

Similarities

Gliatilin, Cerepro, Cereton, Holitilin, Noocholin Rompharma, Choline alphoscerate