Hepatrombin G,ointment 20 g

“Combination drug. Heparin is a direct-acting anticoagulant, when used externally it has antithrombotic, antiexsudative and moderate anti-inflammatory effect; promotes regeneration of connective tissue, prevents blood coagulation in hemorrhoidal nodes.

Prednisolone is a glucocorticoid and has anti-inflammatory, anti-exudative and anti-allergic effects; it reduces inflammation and associated sensations (itching, burning, pain) in the anorectal area.

Polidocanol has a local anesthetic effect and provides sclerosis of hemorrhoidal nodes.”

Indications

External and internal hemorrhoids.

Thrombophlebitis of hemorrhoidal veins of the anus.

Fistulas, eczema and itching in the anus.

Anal fissures.

preparation for surgical intervention in the anorectal area.

as part of complex therapy for thrombosed or operated hemorrhoids.

Pharmacological effect

“Combined drug. Heparin is a direct-acting anticoagulant; when applied externally, it has antithrombotic, antiexudative and moderate anti-inflammatory effects; promotes the regeneration of connective tissue, prevents blood coagulation in hemorrhoids.

Prednisolone is a glucocorticoid that has anti-inflammatory, antiexudative and antiallergic effects; reduces inflammation and associated sensations (itching, burning, pain) in the anorectal area.

Polidocanol has a local anesthetic effect and provides sclerosis of hemorrhoids.”

Special instructions

As with all other corticosteroids, care should be taken not to use the drug in large quantities or for a long time.

The drug does not affect the ability to drive vehicles and potentially dangerous mechanisms.

Active ingredient

Heparin sodium, Lauromacrogol 400, Prednisolone

Active components

Heparin sodium + Prednisolone

Composition

1 g of the drug contains:

active ingredients:

Heparin sodium – 65 IU;

(1 IU sodium heparin – anticoagulant activity, corresponds to the activity of 0.0077 mg II International Heparin Standard (WHO))

Prednisolone acetate – 2.233 mg;

Lauromacrogol 600 – 30.00 mg.

Excipients:

Paraffin paraffin

Liquid paraffin

Lanolin

Silicon dioxide colloidal.

Contraindications

hypersensitivity to the components of the drug;
bacterial, viral, fungal skin lesions;
tuberculosis;
syphilis;
skin tumors (anorectal area);
predisposition to bleeding;
reactions to vaccination;
I trimester of pregnancy.

Side Effects

Systemic reactions: allergic reactions, skin hyperemia.

With long-term use and/or when applied to large surfaces, systemic side effects are possible: slowing down the processes of crack regeneration, swelling.

Prescribing

Direct acting anticoagulant for local use + other drugs

Complete set of goods

Ointment for rectal and external use.

20 g of ointment in an aluminum tube, sealed with a plastic screw cap.

The tube opening is protected by an aluminum membrane.

The lid is a monolithic structure that includes a device for piercing the membrane.

Tube together with a tip and instructions for use in a cardboard box.

Functional features

Heparin

After adsorption, binding to plasma proteins is 95%.

It is released from tissues slowly with a half-life of about 1 hour. 50% of the active substance remains on the skin after administration. The rate of release depends on the dose.

After absorption, it is metabolized in the liver (partially by the enzyme heparinase) and in the reticuloendothelial system.

20-50% is excreted unchanged in the urine and partly as uroheparin, which has a weak anticoagulant effect.

The extent of release is dose dependent (lower doses have a shorter plasma half-life).

Prednisolone

Prednisolone is metabolized in the liver after absorption.

About 1% is excreted unchanged in the urine.

Biological T1/2 is 18-36 hours, and T1/2 from plasma is 115-212 minutes.

Storage conditions

Store at a temperature of 15 to 25°C.

Keep out of the reach of children!

Shelf life

3 years.
Do not use after the expiration date stated on the package.

Manufacturer

Hemofarm A.D., Serbia