Grammidine with anesthetic, spray 112 doses

A combined product for the treatment of infectious and inflammatory diseases of the throat and oral cavity.

The drug contains antimicrobial agent – Gramicidin C, local anesthetic (anesthetic) agent – oxybuprocaine and antiseptic agent – cetylpyridinium chloride.

The mechanism of action of Gramicidin C is associated with increased permeability of the cytoplasmic membrane of the microbial cell, which violates its resistance and causes cell death. Gramicidin C has antibacterial action against a wide range of Gram-positive and Gram-negative microorganisms.

The anesthetic oxybuprocaine has a local anesthetic effect on the mucous membrane of the mouth and throat. Causes a reversible blockade of the propagation and conduction of nerve impulses through the axons of nerve cells.

Cetylpyridinium chloride refers to antiseptic agents. It suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.

The drug has an antimicrobial effect, analgesic effect, reduces inflammation, soothes discomfort in the throat and facilitates swallowing.

Pharmacokinetics

When applied topically, the active ingredients are practically not absorbed from the oral mucosa.

Indications

Infectious and inflammatory diseases of the mouth and throat: pharyngitis, tonsillitis, periodontitis, gingivitis, stomatitis.

Pharmacological effect

A combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity.

The drug contains an antimicrobial agent – gramicidin C, a local anesthetic (pain reliever) – oxybuprocaine and an antiseptic – cetylpyridinium chloride.

The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes cell death. Gramicidin C has an antibacterial effect against a wide range of gram-positive and gram-negative microorganisms.

The anesthetic oxybuprocaine has a local anesthetic effect on the mucous membrane of the mouth and throat. Causes a reversible blockade of the propagation and conduction of nerve impulses through the axons of nerve cells.

Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity.

The drug has an antimicrobial effect, an analgesic effect, reduces inflammation, softens discomfort in the throat, and makes swallowing easier.

Pharmacokinetics

When applied topically, the active substances are practically not absorbed from the oral mucosa.

Special instructions

The drug should not be used if there are open wounds in the oral cavity, since cetylpyridinium chloride slows down wound healing.
The drug contains ethanol. In the maximum single dose of the drug, the ethanol content is up to 0.08 g.

Active ingredient

Gramicidin C, Oxybuprocaine, Citylpyridinium chloride

Composition

One dose of the drug contains:

Active ingredients:

Gramicidin C dihydrochloride – 0.0638 mg (in terms of gramicidin C – 0.06 mg)
Oxybuprocaine hydrochloride – 0.15 mg
Cetylpyridinium chloride – 0.10 mg
Excipients:
Ethanol 96% – 19.00 mg
Sucralose – 0.20 mg
Glycerol – 33.20 mg
Mint flavor – 0.82 mg
Citric acid monohydrate – 0.058 mg
Sodium citrate – 0.022 mg
Polysorbate 80 – 0.40 mg
Methyl parahydroxybenzoate (methylparaben) – 0.184 mg
Propyl parahydroxybenzoate (propylparaben) – 0.02 mg
Purified water – up to 0.2 ml.

Pregnancy

The use of the drug is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Before using the drug, if you are pregnant or think you might be pregnant, or are planning a pregnancy, you should consult your doctor.

There is no data on the penetration of drug components into breast milk. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Contraindications

hypersensitivity to gramicidin C, oxybuprocaine, cetylpyridinium chloride and other components of the drug;
breastfeeding period;
children under 18 years of age.

With caution

Use with caution during pregnancy.

Side Effects

Allergic reactions to the components of the drug, temporary loss of sensitivity of the tongue are possible.

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Currently, there are no cases of clinically significant interactions with other drugs.

Overdose

Symptoms: use of the drug in doses exceeding the recommended ones may cause disorders of the gastrointestinal tract: nausea, vomiting, diarrhea, loss of tongue sensitivity.

Treatment: Stop using the drug and consult a doctor.

Storage conditions

In original packaging at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

2 years.
Do not use after the expiration date stated on the package.

Manufacturer

Delpharm Bladel B.V., Netherlands