Ginkoum, 40 mg capsules 60 pcs

Name: Ginkoum, 40 mg capsules 60 pcs
SKU: 217229
Availability: InStock

€15.53

EAN: 4602242001461 SKU: 217229 Categories: Brain Enhancements, Medicine, Neurology and Psychiatry

Description

Pharmacotherapeutic group Angioprotective agent of plant origin
ATX code: N06DX02

Pharmacological properties

Pharmacodynamics

Increases the body’s resistance to hypoxia, especially brain tissue. Inhibits development of traumatic or toxic cerebral edema, improves cerebral and peripheral blood circulation, improves blood rheology (prevents thrombosis).
It has a dose-dependent regulating effect on the vascular wall, dilates small arteries, increases venous tone. Prevents the formation of free radicals and lipid peroxidation of cell membranes. Normalizes the release, re-uptake and catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to combine with receptors. It improves metabolism in organs and tissues, promotes macroergic accumulation in cells, increased utilization of oxygen and glucose, normalization of mediator processes in the central nervous system.

Pharmacokinetics

absorption
. After oral administration, the bioavailability of the terpenlactones (ginkgolide A, ginkgolide B and bilobalide) is 80% for ginkgolide A, 88% for ginkgolide B and 79% for bilobalide.

Distribution
Peak plasma concentrations were 16-22 ng/mL for ginkgolide A, 8-10 ng/mL for ginkgolide B and 27-54 ng/mL for bilobalide after oral tablets. Binding to plasma proteins is 43% for ginkgolide A, 47% for ginkgolide B and
67% for bilobalide.

Elimation
Half-life is 3.9 hours for ginkgolide A, 4-6 hours for ginkgolide B and 2-3 hours for bilobalide.

Indications
Indications
Concussion and other craniocerebral injuries, Prevention of thrombosis, Stroke sequelae, Attention and memory disorders, Visual impairment, Hearing impairment, Headache, Impaired spatial orientation, Dizziness, Brain circulation disordersSymptomatic treatment of cognitive disorders in adults (memory impairment, reduced concentration and intellectual abilities).
As part of the complex therapy of vertigo of vestibular origin as an adjunctive treatment in addition to vestibular rehabilitation.
Symptomatic treatment of tinnitus (ringing or noise in the ears).

Active ingredient
Active ingredient
Ginkgo biloba leaf extract

Composition
Composition
active ingredient: Ginkgo biloba extract dried, standardized with the content of flavonol glycosides 22.0-27.0% and terpene lactones 5.0-12.0% -0.040 g.
excillary substances: microcrystalline cellulose – 0,109 g, calcium stearate – 0,001 g, hard gelatin capsules (capsule body components: black iron oxide dye E 172, red iron oxide dye E 172, titanium dioxide E 171, yellow iron oxide dye E 172, gelatin;
capsule cap components: dye iron oxide black E 172, dye iron oxide red E 172, titanium dioxide E 171, dye iron oxide yellow E 172, gelatin).

How to take, the dosage
How to take, the dosage
Oral.
Symptomatic treatment of cognitive disorders in adults (memory impairment, decreased concentration and intellectual abilities) take 1-2 capsules 3 times a day.
Complex therapy of vertigo of vestibular origin and symptomatic treatment of tinnitus (tinnitus or tinnitus): 3 capsules per day, spread throughout the day.
The first signs of improvement usually appear after 1 month.
Treatment course of at least 3 months (especially for elderly patients).
Conducting a second course is possible after consultation with the doctor.
If the drug was missed or insufficient amount was taken, the subsequent reception of the drug should be carried out as specified in these instructions without any changes.

Interaction
Interaction
It is not recommended to use the drug in patients who regularly take acetylsalicylic acid, anticoagulants (direct and indirect action), as well as thiazide diuretics, tricyclic antidepressants, anticonvulsants, gentamicin. Single cases of bleeding are possible in patients simultaneously taking medicines that reduce blood clotting, a causal connection of these bleedings with taking medications of ginkgo biloba is not confirmed.
In combination with hypotensive drugs the potentiation of antihypertensive effect is possible.
It is not recommended to use ginkgo bilobate preparations with efavirenz as far as its concentration in blood plasma is decreased due to induction of CYP3A4 cytochrome isoenzyme under the influence of ginkgo bilobate extract.
Study of interaction with thalinolol shows that ginkgo biloba extract may inhibit intestinal P-glycoproteins. This may increase the effect of intestinal P-glycoprotein-sensitive drugs such as dabigatran, so caution should be exercised when using them concomitantly.

Special Instructions
Special Instructions
Do not exceed the recommended doses of the drug.
In case of hypersensitivity reactions the drug should be discontinued. Before surgical intervention it is necessary to inform the doctor about the use of the drug.
In case of frequent feelings of dizziness and tinnitus it is necessary to consult a doctor. In case of sudden deterioration or loss of hearing it is necessary to consult a physician immediately.
Patients with bleeding (hemorrhagic diathesis) and patients receiving anticoagulant therapy should consult a physician before starting therapy with the drug.
It is not recommended to take the drug together with ethanol.
Against the background of the drug in patients suffering from epilepsy, epileptic seizures may occur.
Influence on the ability to drive vehicles and mechanisms
. During the use of the drug care should be taken when performing potentially hazardous activities requiring high concentration and rapid psychomotor reactions (including driving vehicles, operating moving mechanisms), and in case of adverse reactions, including dizziness, one should refrain from driving vehicles.

Synopsis
Synopsis
Solid gelatin capsules from light brown to dark brown in color, size 1. The contents of the capsules – powder or partially crumpled powder from yellow to light brown in color with whitish and dark blotches.
.

Contraindications
Contraindications
Hypersensitivity to the drug components, decreased blood clotting, acute erosive gastritis, acute gastric and duodenal ulcer, acute cerebral circulation disorders, acute myocardial infarction, pregnancy and breast-feeding, children under 18 years (due to insufficient clinical data).
With caution
Use in patients with epilepsy; with arterial hypotension.

Side effects
Side effects
Classification of the frequency of side effects according to the recommendations of the World Health Organization (WHO):
very often
≥ 1/10
often
from ≥ 1/100 to < 1/10
infrequent
from ≥ 1/1000 to < 1/100
rarely
from ≥ 1/10000 to < 1/1000
very rarely
from < 1/10000
frequency is unknown
cannot be estimated from the available data.
In each group, adverse effects are presented in decreasing order of severity.
Digestive system:
very rare: nausea, vomiting, diarrhea.
Nervous system disorders:
very rarely: headache, dizziness, insomnia.
Allergic reactions:
very rarely: hyperemia, edema, itching.
On the hemostatic system:
very rarely: decreased blood clotting. There have been reports of bleeding during prolonged use of Ginkgo biloba preparations in patients who simultaneously took agents that reduce blood clotting.
Sensory organs:
frequency is unknown: hearing impairment.
In case of any adverse events the drug should be discontinued and consult a physician.

Overdose
Overdose
Cases of drug overdose have not yet been registered. In case of overdose, treatment is symptomatic.

Pregnancy use
Pregnancy use
Due to the lack of sufficient clinical data, the use of the drug is contraindicated during pregnancy and breastfeeding.

Similarities
Similarities
Memoplant, Bilobil, Tanakan, Ginkgo Biloba, Bilobil Forte, Bilobil Intens 120

Additional information
Weight 0.033 kg
Shelf life
3 years. Do not use after the expiration date.
Conditions of storage
At a temperature not exceeding 25 ° C, in the original package. Keep out of reach of children.
Manufacturer
Evalar, Russia
Medication form
capsules
Brand
Evalar