Gingkoom, 40 mg capsules 90 pcs

Pharmacotherapeutic group Anhydroprotective agent of plant origin

ATX code: N06DX02

Pharmacological properties

Enhances the body’s resistance to hypoxia, especially brain tissue. Inhibits the development of traumatic or toxic cerebral edema, improves cerebral and peripheral blood circulation, improves blood rheology (prevents thrombosis).

It has a dose-dependent regulatory effect on the vascular wall, dilates small arteries and increases the tone of veins. Prevents the formation of free radicals and lipid peroxidation in cell membranes. Normalizes the release, re-uptake and catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to combine with receptors. It improves metabolism in organs and tissues, promotes the accumulation of macroergens in cells, increased utilization of oxygen and glucose and normalization of mediator processes in the central nervous system.

Pharmacokinetics

absorption

After oral administration, the bioavailability of the terpenlactones (ginkgolide A, ginkgolide B, and bilobalide) is 80% for ginkgolide A, 88% for ginkgolide B, and 79% for bilobalide.

Distribution

The peak plasma concentration was 16-22 ng/mL for ginkgolide A, 8-10 ng/mL for ginkgolide B, and 27-54 ng/mL for bilobalide after oral tablets. Binding to plasma proteins is 43% for ginkgolide A, 47% for ginkgolide B and 67% for bilobalide.

Evolution

The elimination half-life is 3.9 hours for ginkgolide A, 4-6 hours for ginkgolide B and 2-3 hours for bilobalide.

Indications

Active ingredient

Composition

active ingredient: Ginkgo biloba extract dry, standardized with flavonol glycosides 22.0-27.0% and terpene lactones 5.0-12.0% -0.040 g.

excillary substances: microcrystalline cellulose – 0.109 g, calcium stearate – 0.001 g, hard gelatin capsules (capsule body components: black iron oxide dye E 172, red iron oxide dye E 172, titanium dioxide E 171, yellow iron oxide dye E 172, gelatin;

capsule cap components: dye iron oxide black E 172, dye iron oxide red E 172, titanium dioxide E 171, dye iron oxide yellow E 172, gelatin).

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

very often

≥ 1/10

often

from ≥ 1/100 to < 1/10

infrequent

from ≥ 1/1000 to < 1/100

rarely

from ≥ 1/10000 to < 1/1000

very rarely

from < 1/10000

frequency is unknown

cannot be estimated from the available data.

Overdose

Pregnancy use

Similarities