Galavit, rectal, 100 mg 10 pcs
€40.59 €38.38
Pharmacotherapeutic group:
An immunomodulatory and anti-inflammatory agent.
TAC code: L03, G02.
Pharmacological properties:
Pharmacodynamics
The mechanism of action of the drug is associated with its ability to regulate
the functional and metabolic activity of cells of innate and adaptive immunity (monocytes, macrophages, neutrophils, natural killers, etc.). Galavit normalizes phagocytic activity of monocytes/ macrophages, bactericidal activity of neutrophils and cytotoxic activity of NK-cells.
With this, by restoring reduced activity of cells of innate and adaptive immunity, the preparation increases resistance of the body to infectious diseases.
In addition Galavit normalizes antibody formation and increases functional activity (affinity) of antibodies.
In case of inflammatory diseases the preparation reversibly inhibits for 6-8 hours the excessive synthesis by hyperactivated macrophages of tumor necrosis factor-α, interleukin-1, interleukin-6 and other pro-inflammatory cytokines the level of which determines the degree of inflammatory reactions, their
cyclic activity as well as the severity of intoxication of the body. Galavit decreases the production of reactive oxygen species by hyperactivated macrophages, thus reducing the level of oxidative stress and protecting tissues and organs from the damaging effects of radicals.
The drug has no allergizing, mutagenic, embryotoxic, teratogenic and carcinogenic action.
Pharmacokinetics
Extracted from the body mainly through the kidneys. After rectal administration
The elimination half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours. Aminodihydrophthalazindione sodium in suppositories when administered rectally has high bioavailability, due to which both local and expressed systemic effects are achieved.
Indications
Hepatitis, Otitis, Boils, Periodontitis, Gastric and 12 duodenal ulcers, Oral inflammation, Herpes, Colds, Urinary tract infections, Diarrhea, Tonsillitis, Sore throat, Alcoholism, Bronchitis
As an immunomodulatory and anti-inflammatory agent in the treatment of immunodeficiency disorders in adults and adolescents over 12 years:
– infectious and inflammatory urogenital diseases (urethritis of chlamydial and trichomonadic etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, endometritis);
– pelvic inflammatory diseases;
– chronic recurrent disease caused by the herpes virus;
– disease caused by the papilloma virus;
– Postoperative rehabilitation of patients with uterine myoma;
– complications of postoperative period in women of reproductive age;
–
Postoperative septic complications and their prevention (including those in cancer patients);
Chronic recurrent furunculosis, rust;
Nonspecific prevention and treatment of influenza and acute respiratory infections.
– inflammatory diseases of the mucous membranes of the mouth and throat,
Parodontal diseases;
– viral hepatitis;
– infectious intestinal diseases with intoxication and/or diarrhea;
– gastric and 12 duodenal ulcer;
– asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including athletes); mental, behavioral and postabstinence disorders with alcohol and drug abuse.
Active ingredient
Sodium aminodihydrophthalazindione
Composition
Active ingredient:
Sodium aminodihydrophthalazindione (Galavit®) – 100 mg;
Auxiliary substances:
vitepsol W-35 (fatty acid glycerides) – 575 mg,
vitepsol H-15 (fatty acid glycerides) – 575 mg.
How to take, the dosage
Rectally. The suppository is freed from the contoured package and then inserted into the rectum. It is recommended to free the intestine beforehand.
The dose and duration of use of the drug depends on the nature, severity and duration of the disease.
– In urogenital diseases – urethritis of chlamydial and trichomonadic aetiology, chlamydial prostatitis: 1 day 1 suppository twice, then one every other day. The course of 10-15 suppositories (depending on the severity of the pathological process).
– In salpingo-oophoritis, endometritis in the acute period: 2 days of 2 suppositories once a day, then one suppository at intervals of 72 hours. In the chronic period: 5 days with 1 suppository once a day, then one suppository every 72 hours. The course is 20 suppositories.
– In acute and chronic purulent diseases of the pelvic organs – in the acute period: 1 day 2 suppositories once, 3 days one suppository daily, then one every other day for 5 days. The course of 10 suppositories. In the chronic period: 5 days 1 suppository once daily, then one every 72 hours. The course is 20 suppositories.
– In chronic relapsing diseases caused by the herpes virus: 1 suppository daily 5 suppositories, then 1 suppository every other day – 15 suppositories.
– In diseases caused by the papilloma virus: 5 days 1 suppository once a day, then 1 suppository every other day. The course is 20 suppositories.
– For postoperative rehabilitation of patients with uterine myoma and complications of the postoperative period in women of reproductive age: 5 days with 1 suppository once a day, then one suppository every other day. The course is 15 suppositories.
– For prevention and treatment of surgical complications in pre- and postoperative period (including cancer patients): 1 suppository 1 time daily – 5 suppositories before surgery, 5 suppositories after surgery – 1 every other day and 5 suppositories – with interval of 72 hours. If the course of the disease is severe, the initial dose is 2 suppositories once or twice a day with one suppository. The course of treatment is 20 suppositories.
– For non-specific prevention and treatment of influenza and acute respiratory infections: one suppository once a day. The course of 5 days.
For inflammatory diseases of the oral cavity and throat, periodontal diseases: the initial dose of 1 suppository daily – 5 suppositories, then one suppository at intervals of 72 hours. The course of 15 suppositories.
– In viral hepatitis: the initial dose is 2 suppositories once, then one suppository twice a day until relief of symptoms of intoxication and inflammation. Subsequent continuation of the course of 1 suppository at intervals of 72 hours. The course of 20-25 suppositories.
– In acute infectious intestinal diseases accompanied by diarrheal syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until relief of symptoms of intoxication. Further continuation of the course of 1 suppository at intervals of 72 hours is possible. The course of 20-25 suppositories.
– With gastric and 12 duodenal ulcers in the acute period: 2 days with 2 suppositories once a day, then 1 suppository with an interval of 72 hours. The course of 15-25 suppositories. In the chronic period: 5 days, 1 suppository 1 time a day, then 1 suppository 72 hours apart. The course of 20 suppositories.
– In asthenic conditions, neurotic and somatoform disorders, in mental, behavioral and postabstinence disorders, in patients with alcohol and drug dependence: 5 days with one suppository daily, then one suppository every 72 hours. The course of 15-20 suppositories.
– To increase physical performance: 1 suppository every other day – 5 suppositories, then one suppository every 72 hours, the course is up to 20 suppositories.
Interaction
With concomitant use it is possible to reduce the course doses of antibiotics. Cases of incompatibility with other drugs have not been reported.
Special Instructions
To prevent urogenital infection, it is recommended to consider simultaneous treatment of the sexual partner.
Effect on the ability to drive vehicles, mechanisms: Has not been studied.
Synopsis
The suppositories are white to white with a yellowish tint, torpedo-shaped with no visible blotches on the longitudinal slice.
Contraindications
Hypersensitivity to Galavit and other components of the drug, pregnancy and lactation, children under 12 years of age.
Side effects
Allergic reactions may occur in rare cases. If you experience or worsen any of the side effects mentioned in the instructions, or if you notice any other side effects not mentioned in the instructions, please tell your doctor.
Overdose
No cases of overdose have been reported.
Pregnancy use
The use of the drug is contraindicated in pregnancy and during breast-feeding.
Weight | 0.024 kg |
---|---|
Shelf life | 3 years. Do not use after the expiration date printed on the carton. |
Conditions of storage | Store at a temperature not exceeding 25 ° C in a light-protected place. Keep out of reach of children. |
Manufacturer | Selvim, Russia |
Medication form | rectal suppositories |
Brand | Selvim |
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