Folic acid tablets, 1 mg 50 pcs

How to take, the dosage

Inside. Before meals. It is allowed to crush the tablet before intake for children and persons who have difficulty in swallowing.

Interaction

Decreases the effect of phenytoin (requires increasing its dose).

Analgesics (long-term therapy), anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid. Antacids (including preparations of Ca2+, Al3+ and Mg2+), cholestyramine, sulfonamines (including sulfasalazine) reduce absorption of folic acid.

In order to prevent megaloblastic anemia in patients taking cytostatics (methotrexate) or antiepileptic drugs, concomitant administration of folic acid is recommended.

Pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and decrease the effect of folic acid (patients taking these drugs should be given calcium folinate instead).

There is no definitive information about Zn2+ preparations: some studies show that folate inhibits absorption of Zn2+, others refute this data.

Special Instructions

The drug is not intended to prevent hypo- and avitaminosis in children (because of the mismatch between the daily requirement and the dosage of the drug).

For the prevention of hypovitaminosis B9 a balanced diet is most preferable. Foods rich in vitamin B9 are green vegetables (lettuce, spinach, tomatoes, carrots), fresh liver, legumes, beets, eggs, cheese, nuts, cereals.

Folic acid is not used for the treatment of B12-deficiency (pernicious), normocytic and aplastic anemia as well as for anemia refractory to therapy. In pernicious (B12-deficient) anemia folic acid, while improving hematological parameters, masks neurological complications. While pernicious anemia is not excluded, administration of folic acid in doses greater than 0.1 mg/day is not recommended (except for pregnancy and lactation).

Patients on hemodialysis need more folic acid.
During treatment, antacids should be used 2 hours after folic acid; cholestyramine should be used 4 to 6 hours before or 1 hour after folic acid administration.

Please note that antibiotics can distort (deliberately underestimate) the results of microbiological assessment of plasma and erythrocyte folic acid concentration.

When using high doses of folic acid, as well as therapy for a long period may decrease the blood concentration of vitamin B12 (cyanocobalamin). Long-term use of folic acid is recommended to be combined with taking vitamin B12.

Impact on the ability to drive and work with moving mechanisms:

No effect.

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Contraindications

Hypersensitivity to the components of the drug (TS).

Overdose

Doses of folic acid up to 4 to 5 mg are well tolerated.

Higher doses may cause: disorders of the central nervous system (irritability and insomnia) and the gastrointestinal tract (nausea, abdominal pain, flatulence).

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Pregnancy use

The drug is used under indications in pregnancy and during lactation. Daily intake of folic acid in early pregnancy can prevent neural tube defects of the fetus (anencephaly, spina bifida).

If the drug is started after the fourth week of pregnancy, folic acid is not effective in preventing neural tube defects.