9 Months Folic Acid, 400 mcg 90 pcs

Name: 9 Months Folic Acid, 400 mcg 90 pcs
SKU: 299809
Availability: InStock

€9.32

EAN: 4602193010109 SKU: 299809 Categories: Folic Acid, Supplements

B-group vitamin (vitamin B9, vitamin BV), can be synthesized by intestinal microflora. In the body is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for normal maturation of megaloblasts and formation of normoblasts.
Stimulates erythropoiesis, participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, pyrimidines, purines and in the exchange of histidine and choline.

Pharmacokinetics

Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum. It is almost completely bound to plasma proteins.

It is activated in the liver under the influence of the enzyme dihydrofolate reductase, converting into tetrahydrofolic acid. Maximal concentration in blood (Cmax) is reached after 30-60 minutes. It penetrates through the blood-brain barrier and placental barrier into breast milk.

It is excreted by the kidneys mainly as metabolites, and if the dose received significantly exceeds the daily requirement for folic acid it is excreted unchanged. Excreted with hemodialysis.

Indications
Indications
Folic acid deficiency.
Prevention of neural tube defects in the fetus in the first trimester of pregnancy.

Composition
Composition
1 tablet contains:
Active ingredient:
folic acid – 0.0004 g.
Excipients:
lactose monohydrate – 0.0936 g,
colloidal silica – 0.0005 g,
copovidone – 0.0050 g,
magnesium stearate – 0.0005 g.
Tray: OpadrayII 85F22233 – 0,0030 g: partially hydrolyzed polyvinyl alcohol – 40,00%, macro-gol – 20,20%, talc – 14,80%, titanium dioxide E 171 – 19,50%, iron oxide yellow dye E 172 – 0,10%, aluminum lacquer based on quinoline yellow dye E 104 – 5,40%.

How to take, the dosage
How to take, the dosage
With folic acid deficiency – 400 micrograms (1 tablet) per day.
For the prevention of neural tube defects in the fetus in the first trimester of pregnancy – 400 micrograms – 800 micrograms (1 – 2 tablets).

Interaction
Interaction
Decreases the effectiveness of phenytoin (requires increasing its dose). Analgesics (long-term therapy), anticonvulsants (including Phenytoin and carbamazepine). Estrogens and oral contraceptives increase the folic acid requirement.
Antacids, colestyramine, sulfonamines (including sulfasalazine) reduce absorption of folic acid.
Special Instructions
Special Instructions
For the prevention of hypovitaminosis, a balanced diet is most preferable. Foods rich in folic acid – green vegetables (lettuce, spinach, tomatoes, carrots), fresh liver, legumes, beets, eggs, cheese, nuts, cereals.
Folic acid is not used to treat B12-deficient (pernicious), normocytic and aplastic anemia, as well as anemia refractory to therapy. In pernicious (B12-deficient) anemia folic acid, while improving hematological parameters, masks neurological complications. While pernicious anemia is not excluded, folic acid administration in doses greater than 100 mcg/day is not recommended (except for pregnancy and lactation).
It should be kept in mind that patients on hemodialysis require increased folic acid doses.
During treatment, antacids should be used 2 h after folic acid intake, colestyramine – 4-6 h before or 1 h after folic acid intake. It should be borne in mind that antibiotics may distort (give knowingly underestimated values) the results of microbiological assessment of folic acid concentration of plasma and erythrocytes.
When using high doses of folic acid, as well as therapy for a long period, the concentration of vitamin B12 may decrease.
Synopsis
Synopsis
Round biconvex, yellow film-coated tablets. On the cross section the nucleus is light yellow with flecks.
Contraindications
Contraindications
Hypersensitivity to the ingredients of the drug, pernicious anemia, malignant tumors, cobalamin deficiency, childhood.
Overdose
Overdose
May occur with prolonged use (more than 1-2 months) of folic acid in doses greater than 1000 mcg per day and as a result of combined use with vitamin-mineral complexes.
Pregnancy use
Pregnancy use
Folic acid is necessary in preparation for pregnancy (1-3 months before the planned pregnancy) and in the first few weeks after conception (I trimester).
Additional information
Weight 0.036 kg
Shelf life
3 years.
Conditions of storage
The drug should be stored in a dry place, protected from light, out of reach of children at a temperature not exceeding 25 ° C.
Manufacturer
Valenta Farm, Russia
Medication form
pills
Brand
Valenta Farm