Fluimucil, 600 mg 20 pcs.

How to take, the dosage

1 tablet is dissolved in 1/3 cup of water and taken once a day.

The duration of treatment should be assessed individually.

In acute diseases the duration of treatment is from 5 to 10 days and up to several months in the treatment of chronic diseases (according to the doctor’s recommendation).

Interaction

Combined use of acetylcysteine with cough suppressants may increase sputum stasis due to suppression of the cough reflex.

In concomitant use with such antibiotics as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to decreased activity of both drugs. Therefore, the interval between the intake of these drugs should be at least 2 h.

The simultaneous use of acetylcysteine and nitroglycerin may increase the vasodilator and antiplatelet effect of the latter.

Acetylcysteine eliminates the toxic effects of paracetamol.

Special Instructions

The drug contains aspartame, so it is not recommended to prescribe it to patients with phenylketonuria (granules, effervescent tablets).

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Contraindications

• high sensitivity to simvastatin or other drug components as well as to other statin drugs (HMK-CoA reductase inhibitors) in the anamnesis;
• Hepatic diseases in the active phase, persistent increase in liver enzyme activity of unknown etiology;
• skeletal muscle disease (myopathy);
• lactose intolerance; lactase deficiency; glucose-galactose malabsorption;
• age
• under 18 years of age (except children and adolescents 10-17 years of age with heterozygous familial hypercholesterolemia);
Simultaneous use with strong CYP3A4 isoenzyme inhibitors (itraconazole ketoconazole pozaconazole HIV protease inhibitors boceprevir telaprevir erythromycin clarithromycin gelithromycin nsfazodone voriconazole and preparations containing cobicistat);
• concomitant treatment with gemfibrozil with cyclosporine or danazol
• use in women planning a pregnancy and women of reproductive age who do not use reliable contraception
• pregnancy
• the period of breastfeeding.

With caution: Simvastatin is prescribed with caution to patients abusing alcohol to patients after organ transplantation who are treated with immunosuppressants (due to the increased risk of rhabdomyolysis and renal failure); In conditions that may lead to the development of severe renal insufficiency, such as arterial hypotension acute infectious diseases of severe course expressed metabolic and endocrine disorders disorders of water-electrolyte balance surgical interventions (including dental) or trauma; Patients with decreased or increased skeletal muscle tone of unknown etiology; patients with epilepsy; patients with severe renal insufficiency (creatinine clearance (CK) less than 30 ml/min); patients with hereditary muscle diseases; patients with high risk of diabetes mellitus; elderly patients (over 65 years); when concomitant use with lipid-lowering nicotinic acid (more than 1 r/day) amio-darone amlodipine veranamil dil thiazem colchicine fuscic acid ranolazine dronedarone (increased risk of myopathy and rhabdomyolysis) grapefruit juice.

Side effects

When taken orally in rare cases nausea, heartburn, vomiting, diarrhea, skin rash, itching, urticaria, nasal bleeding, tinnitus may occur.

In cases of bronchospasm, collapse, stomatitis, decreased platelet aggregation have been described.

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Pregnancy use

Pregnant and breastfeeding use is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or baby.

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Similarities

Atsc, Atsc 200, Atsc-long, Acetylcysteine, Fluimucil, Acetylcysteine Canon, Espa-Naz, Eifa AC