Flamax forte, 100 mg 20 pcs

Flamax Forte is a non-steroidal anti-inflammatory drug, a derivative of propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects, inhibits platelet aggregation.

Empacting on cyclooxygenase and lipooxygenase link of arachidonic acid metabolism, ketoprofen inhibits the synthesis of prostaglandins, leukotrienes and thromboxanes.

The analgesic effect is due to both central and peripheral mechanisms.

It has anti-bradykinin activity and stabilizes lysosomal membranes.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system:

rheumatoid, psoriatic arthritis,
Bechterew’s disease (ankylosing spondylitis),
gouty arthritis (in case of an acute attack of gout, fast-acting dosage forms are preferred),
osteoarthritis.

Pain syndrome:

myalgia,
ossalgia,
neuralgia,
tendinitis,
arthralgia,
bursitis,
radiculitis,
adnexitis,
otitis,
headache and toothache,
for oncological diseases,
post-traumatic and postoperative pain syndrome accompanied by inflammation.

Pharmacological effect

Flamax Forte is a non-steroidal anti-inflammatory drug, a derivative of propionic acid.

It has an analgesic, anti-inflammatory and antipyretic effect, suppresses platelet aggregation.

By acting on the cyclooxygenase and lipoxygenase components of arachidonic acid metabolism, ketoprofen inhibits the synthesis of prostaglandins, leukotrienes and thromboxanes.

The analgesic effect is due to both central and peripheral mechanisms.

It has anti-bradykinin activity and stabilizes lysosomal membranes.

Special instructions

Flamax Forte is prescribed with extreme caution to patients with liver and kidney diseases, diseases of the gastrointestinal tract, and immediately after major surgical interventions.

During treatment with the drug, systematic monitoring of liver and kidney function is necessary.

When prescribed simultaneously with anticoagulants, the risk of bleeding increases.

Active ingredient

Ketoprofen

Composition

1 film-coated tablet contains 100 mg of ketoprofen;

Excipients:

lactose monohydrate,

rice starch,

croscarmellose sodium,

povidone,

microcrystalline cellulose,

magnesium stearate,

sodium lauryl sulfate,

colloidal silicon dioxide,

hypromellose,

macrogol 6000,

talc,

titanium dioxide,

brilliant blue.

Pregnancy

Flamax Forte is contraindicated during pregnancy, breastfeeding and children under 15 years of age.

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract in the acute phase
“aspirin” asthma
severe impairment of liver and/or kidney function
hypersensitivity to the drug Flamax Forte, hemorrhoids for the use of suppositories, skin diseases and wounds for the use of the gel.

Side Effects

nausea,
vomit,
constipation or diarrhea,
stomach pain
headaches,
dizziness,
drowsiness
allergic reactions in the form of skin rash
erosive and ulcerative lesions of the gastrointestinal tract
bleeding of the gastrointestinal tract.

Interaction

Reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of glucocorticosteroids and mineralocorticosteroids, estrogens; reduces the effectiveness of antihypertensive drugs and diuretics.

Combined use with other NSAIDs, glucocorticosteroids, ethanol, corticotropin can lead to the formation of ulcers and the development of gastrointestinal bleeding, increasing the risk of developing renal dysfunction.

Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefaperazone, cefamandole and cefotetan increases the risk of bleeding.

Increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (dose recalculation is necessary). Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.

Co-administration with sodium valproate causes disruption of platelet aggregation.

Increases plasma concentrations of verapamil and nifedipine, lithium preparations, methotrexate. Antacids and cholestyramine reduce absorption.

Myelotoxic drugs enhance the manifestations of hematotoxicity of the drug.

Overdose

Symptoms: drowsiness, nausea, vomiting, abdominal pain, bleeding, liver and kidney dysfunction may occur.

Treatment is symptomatic: gastric lavage and/or activated carbon and/or other sorbents. There is no specific antidote.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Replek Farm, Republic of North Macedonia