Dolgit, cream 5% 50 g

The drug has a local anesthetic, anti-inflammatory and anti-edema effect. It suppresses the production of inflammatory mediators. It indiscriminately blocks cyclooxygenase (COX-1 and COX-2) and has inhibitory effect on the synthesis of prostaglandin E2 (PGE2), prostacyclin (PGI2) and thromboxane B2 (TV2).

The analgesic effect is most pronounced in pain of inflammatory nature. Causes reduction or disappearance of the pain syndrome, including pain at rest and on movement; reduces morning stiffness and joint swelling. Helps increase range of motion. In addition to its anti-inflammatory effect, ibuprofen reduces platelet aggregation in the inflamed area, as well as migration of leukocytes and release of lysosomal enzymes in the inflamed area.

Ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations in the skin when the cream is applied.

Therapeutic effect in the area of application is achieved by direct distribution through the skin to the target tissues. In a small amount is determined in the blood plasma. With the recommended method of application the concentration in synovial fluid is about 2 µg/ml.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system:
Arthritis (rheumatoid, psoriatic).
Articular syndrome in rheumatism and exacerbation of gout.
Humoscapular periarthritis.
Ankylosing spondylitis (ankylosing spondylitis).
Deforming osteoarthritis.
Osteochondrosis with radicular syndrome.
Radiculitis.
Sciatica.
Myalgia (rheumatic and non-rheumatic origin).
Lumbago.
Tendivit, tenosynovitis, bursitis.
Injuries (sports, industrial, household) without violating the integrity of soft tissues (including dislocations, sprains, ruptures of muscles or ligaments, bruises, post-traumatic swelling of soft tissues).

Pharmacological effect

The drug has a local analgesic, anti-inflammatory and anti-edematous effect. Suppresses the production of inflammatory mediators. Indiscriminately blocks cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin E2 (PGE2), prostacyclin (PGI2) and thromboxane B2 (TB2).

The analgesic effect is most pronounced for inflammatory pain. Causes a decrease or disappearance of pain, including pain at rest and during movement; reduces morning stiffness and swelling of joints. Helps increase range of motion. In addition to the anti-inflammatory effect, ibuprofen reduces platelet aggregation at the site of inflammation, as well as the migration of leukocytes and the release of lysosomal enzymes in the area of ​​inflammation.

When applying the cream to the skin, ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations there.

The therapeutic effect in the area of ​​application is achieved by direct distribution through the skin into the target tissue. It is detected in small quantities in blood plasma. With the recommended method of application, the concentration in the synovial fluid is about 2 μg/ml.

Special instructions

The drug should not be applied to open wound surfaces, damaged skin or mucous membranes (avoid contact with eyes).

If the therapy is ineffective, you should consult a doctor.

In severe cases, it is recommended to combine local therapy with oral NSAIDs.

– Use in pediatrics Dolgit in cream form should not be used in children under 12 years of age without consulting a doctor.

– Impact on the ability to drive vehicles and operate machinery. The use of Dolgit cream does not affect activities that require increased attention, coordination of movements, high speed of mental and physical reactions (including for transport drivers, persons servicing cars).

Active ingredient

Ibuprofen

Composition

100 g of cream contains 5 g of the active substance ibuprofen;

Contraindications

Hypersensitivity to ibuprofen, components of the drug and other NSAIDs, weeping dermatoses, eczema, violations of the integrity of the skin (including infected abrasions and wounds) at the site of application of the cream; pregnancy, lactation period; children up to 14 years of age.

Side Effects

Usually the drug is well tolerated.

Interaction

You should consult your doctor before using Dolgit cream if you are using other medications.

When ibuprofen was used externally, no interactions with other drugs were identified.

Overdose

Cases of overdose with Dolgit cream have not been described.

Symptoms: if the drug is accidentally ingested, nausea and vomiting may occur.

Treatment: you should empty your stomach (induce vomiting, take activated charcoal) and consult a doctor. Further treatment, if necessary, is symptomatic.

Storage conditions

Store in a dry place at a temperature of 15° to 25°C.
Keep out of the reach of children.
Do not use after expiration date.

Shelf life

3 years.

Manufacturer

Dolorgit GmbH and Co. KG, Germany