Derinat, 0.25% 10 ml

Derinat – stimulates hematopoiesis, regenerating, reparative, wound healing, immunomodulatory.

Pharmacodynamics

The drug has a modulating effect on cellular and humoral parts of the immune system and non-specific resistance of the body, which leads to optimization of the inflammatory response and specific immune response to bacterial, viral and fungal antigens.

The immunomodulatory effect of Derinat® is due to its ability to stimulate B-lymphocytes, activate T-helpers and cells of monocytic-macrophage system. The drug accelerates energy metabolism inside the cell, synthesis of RNA and DNA. Activation of cellular immunity by Derinat® increases the ability of natural killer cells to attack cells affected by viruses, chlamydia, Staphylococcus aureus, E. coli, Helicobacter and others. Derinat® stimulates reparative and regenerative processes.

The drug has anti-inflammatory, anti-tumor, anti-allergic and detoxifying effects, as well as antioxidant and membrane stabilizing properties. Derinat® normalizes the condition of the body in dystrophies of vascular origin and has a weak anticoagulant effect.

Derinat® helps remove free radicals from the body, reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs.

In the body the drug mainly accumulates in the organs of the immune system and hematopoiesis – bone marrow, spleen, lymph nodes, and also in the epithelium of the intestine.

It increases the body’s resistance to infections. Stimulates hematopoiesis (by normalizing the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets).

It has cardioprotective, anti-ischemic and cytoprotective effects. Including Derinat® in treatment of patients with coronary heart disease improves myocardial contractile function, prevents cardiomyocyte death and increases exercise tolerance.

In gastric and duodenal ulcer the reparative effect of the drug, restoration of the mucous membrane and a pronounced immunomodulatory effect aimed at elimination of the infectious factor Helicobacter pylori are noted.

The drug has no embryotoxic, teratogenic and carcinogenic actions.

Indications

Active ingredient

Composition

1 ml of the solution contains:

Active substance:

Sodium deoxyribonucleate 2.5 g;

Associates:

Sodium chloride – 1 g;

water for injection – up to 1000 ml.

How to take, the dosage

Outwardly, topically.

The drug is prescribed to children from the first day of life and adults.

For prevention of SARS – 2 drops 2-4 times a day for 1 month in each nasal passage. When symptoms of colds appear – every 1-1.5 hours during the day, then – 2-3 drops in each nostril 3-4 times a day for 7-10 days (until recovery). In inflammatory diseases of the nasal cavity and sinuses – 3-5 drops in each nasal passage 3-6 times a day or place cotton swabs with the drug in each nasal passage 1-2 times a day for 5-10 minutes, the course duration – 1-2 weeks.

In chronic inflammatory diseases; fungal, bacterial and other infections and mucous membrane integrity disorders in gynecological practice – intravaginal injection followed by cervical irrigation or intravaginal administration of tampons with the drug, 5 ml per session 1-2 times a day for 10-14 days.

Inflammatory eye diseases of viral and bacterial nature (conjunctivitis, keratitis, adenoviral keratoconjunctivitis, uveitis, maculitis, blepharitis) – 2 drops 4-6 times a day, the course – from 10 days to 1-3 months.

Injuries to the eye, to accelerate the healing process during surgical interventions – 2 drops 5 times a day, the course – 1-3 months.

Eye irritation (including “computer vision syndrome”), progressive myopia and accommodation spasm – 2 drops 3 times a day for a month.

In case of diseases of the oral mucosa (stomatitis, gingivitis, aphthous ulcers) the drug is used to rinse 4-6 times a day (1 vial – 1-2 rinses). The course of treatment is 5-10 days.

In proctology it is used in the form of microclysters in the rectum in 15-40 ml, the course of treatment is 7-14 days.

In case of post-radiation necrosis of skin and mucous membranes, in wounds which do not heal for a long time, burns, frostbite, trophic ulcers of different etiology and gangrene the application of gauze bandages (double layer) is carried out on the affected sites and the drug is applied 3-4 times a day along with simultaneous nose drops in 1 – 2 drops 6 times a day (treatment course 1-3 months).

Interaction

Combined use with other drugs may increase the therapeutic effect of Derinat.
When used together, Derinat may increase the effect of anticoagulants.

Special Instructions

In order to reduce painfulness when injected into the body, it is recommended that the drug be injected slowly for 1-2 minutes.

It is not allowed to inject Derinat into the body!

Just before the drug is injected, the bottle with the solution should be warmed in the hand to body temperature.

Contraindications

Individual intolerance.

Side effects

Local reactions: moderate soreness at the injection site.

Possible reaction: hypoglycemia (in diabetic patients); in some cases – 1.5-3 hours after the injection, short-term hyperthermia, which is stopped by the use of symptomatic drugs.

Overdose

The information is not described.

Pregnancy use

The patient should be warned that before using the drug during pregnancy and lactation a medical consultation is necessary.

If it is necessary to prescribe the drug in pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed.