Corvalol Fito, drops 50 ml

Sedative

Pharmacodynamics

A combined drug, the action of which is caused by the properties of its constituent substances. It has sedative and antispasmodic effects, moderate cardiotonic effect (slows the rhythm and increases the force of the heart beats), and has moderate hypotensive properties.

Ethylbromisovalerianat has sedative and antispasmodic effect caused by irritation, mainly of receptors in the oral cavity and nasopharynx, reduction of reflex excitability in central nervous system and increased inhibition in cortical and subcortical structures of the brain, also by decrease of activity of central vasomotor centers and direct local spasmolytic effect on smooth muscles.

The motherwort herb has a pronounced sedative (sedative), moderate cardiotonic (slows rhythm and increases the force of heart contractions), moderate hypotensive action.

Pearmint oil has reflex vasodilatory, antispasmodic, mild choleretic, antiseptic action. The mechanism of action is related to the ability to irritate the “cold” receptors of the oral mucosa and reflexively dilate mainly vessels of the heart and brain. It eliminates the phenomena of flatulence by irritating the mucosal receptors of the gastrointestinal tract (GIT), increasing intestinal peristalsis.

Pharmacokinetics

There are no data on the pharmacokinetics of ethylbromisovalerianate, motherwort and peppermint components.

Indications

Sleep disturbances, neurosis-like states, accompanied by increased irritability and excitability, states of excitement with pronounced vegetative manifestations;

As an antispasmodic agent for intestinal spasms, and also as a symptomatic (sedative and vasodilator) agent for functional disorders of the cardiovascular system.

Pharmacological effect

Sedative

Pharmacodynamics

A combined drug whose effect is determined by the properties of its constituent substances. It has a sedative and antispasmodic effect, a moderate cardiotonic effect (slows down the rhythm and increases the strength of heart contractions), and has moderate hypotensive properties.

Ethyl bromizovalerianate has a sedative and antispasmodic effect due to irritation, mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscles.

Motherwort herb has a pronounced sedative (calming), moderate cardiotonic (slows down the rhythm and increases the force of heart contractions) effect, and moderate hypotensive effect.

Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the “cold” receptors of the oral mucosa and reflexively dilate mainly the vessels of the heart and brain. Eliminates flatulence by irritating receptors in the mucous membrane of the gastrointestinal tract (GIT), enhancing intestinal motility.

Pharmacokinetics

Data on the pharmacokinetics of ethyl bromoisovalerate, motherwort and peppermint components are not available.

Special instructions

There is no experience in using the drug in children under 18 years of age, during pregnancy and breastfeeding. Long-term use of the drug in high doses is not recommended due to possible toxic effects due to the accumulation of bromine in the body. You should not drink alcohol while using the drug.

Corvalol Phyto contains 47.5% ethyl alcohol, so when taken orally in the maximum single dose of the drug, the content of absolute ethyl alcohol (ethanol) is 0.308 g, in the maximum daily dose – 0.923 g.

Impact on the ability to drive vehicles and machinery

Due to the possibility of dizziness, decreased concentration and other side effects associated with taking the drug, during the treatment period patients are advised to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor and motor reactions.

Active ingredient

Peppermint Leaf Oil, Motherwort Herb Extract, Ethyl Bromoisovalerianate

Composition

Composition per 1 ml:

Active ingredients: motherwort herb tincture – 720.00 mg; ethylbromoisovalerate – 20.00 mg; peppermint leaf oil (peppermint oil) -1.42 mg.

Excipients: purified water – up to 1 ml.

To obtain 100 ml of motherwort tincture, use 20 g of motherwort herb and a sufficient amount of 70% ethyl alcohol.

Pregnancy

The safety of Corvalol Phyto during pregnancy has not been established and its use during this period is contraindicated. There is no data on the penetration of the drug components into breast milk, therefore, if use during breastfeeding is necessary, the issue of stopping breastfeeding should be decided.

Contraindications

– hypersensitivity to the components of the drug;

– severe renal and/or liver dysfunction;

– erosive and ulcerative lesions of the gastrointestinal tract (acute phase);

– pregnancy;

– period of breastfeeding;

– children under 18 years of age (efficacy and safety have not been established).

With caution

– Impaired liver and/or kidney function;

– Epilepsy;

– Alcoholism;

– Patients at high risk, including those with liver disease, traumatic brain injury, and brain diseases.

Side Effects

From the immune system: allergic reactions;

From the central nervous system: drowsiness, weakness, dizziness, decreased ability to concentrate;

From the cardiovascular system: slow heart rate;

From the gastrointestinal tract: dyspepsia.

These phenomena disappear when the dose of the drug is reduced or the drug is stopped. With long-term use of high doses of the drug, it is possible to develop drug dependence, as well as the accumulation of bromine in the body and the development of bromism phenomena, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.

Interaction

With the simultaneous use of the drug Corvalol Fito with drugs that depress the activity of the central nervous system (sedatives, hypnotics, neuroleptics, tranquilizers), mutual enhancement of the effects is possible. Enhances the effect of antispasmodics and analgesics. Alcohol enhances the effect of the drug and its toxicity.

Overdose

Overdose is possible with frequent and prolonged use of the drug. If recommended doses are exceeded, dose-dependent side effects may increase.

Symptoms: weakness, drowsiness, dizziness. With long-term use, chronic intoxication with bromine may occur (See section Side effects).

Treatment: symptomatic.

Short product description

The intense pace of life and daily stress contribute to anxiety and irritability.

Corvalol Phyto is a combination drug that can reduce symptoms of stress.

It has a mild sedative and hypotensive effect, helps normalize heart rate, as well as reduce other manifestations of stress.

Storage conditions

Store at a temperature not exceeding 25 oC.

Keep out of the reach of children.

Shelf life

2 years

Manufacturer

Pharmstandard-Leksredstva, Russia