Clopixol-acufaz, 50 mg/ml oil 1 ml 5 pcs

Pharmgroup:

Antipsychotic (neuroleptic).

Pharmic action:

Antipsychotic (neuroleptic), a thioxanthene derivative. Clopixol has pronounced antipsychotic and specific inhibitory effects.

Clopixol may also have a transient, dose-dependent sedative effect, the rapid development of which at the beginning of therapy (before the onset of antipsychotic action) is an advantage in the treatment of acute and subacute psychosis. Tolerance to the nonspecific sedative effect of the drug occurs quickly.

The drug is especially indicated for agitation, anxiety, hostility, or aggressiveness because of its specific inhibitory effect.

A single injection of Clopixol-Acufase provides a pronounced and rapid relief of psychotic symptoms. The duration of the antipsychotic effect of the drug after one injection is 2-3 days.

The nonspecific sedative effect is seen after 2 h, reaches a maximum after about 8 h, after that it is significantly reduced and is weak with repeated injections.

The therapeutic effect of Clopixol depot is significantly more prolonged compared to Clopixol. This allows for confidence in continuous antipsychotic treatment with Clopixol Depot, which is especially important for patients who do not follow physician’s orders.

Clopixol depot prevents the development of frequent relapses associated with patients arbitrarily interrupting oral medications.

Indications

Acute and chronic schizophrenia and other psychotic disorders, especially with hallucinations, paranoid delusions and thought disorders; states of agitation, increased anxiety, hostility, aggressiveness.

Active ingredient

Zuclopentixol

Composition

1 ml:

– zuclopentixol acetate 50 mg

Excipients:

Triglycerides.

How to take, the dosage

Clopixol-acufase is administered as a deep intramuscular injection into the upper outer quadrant of the gluteal region. Local tolerance is good. The dosage is adjusted individually depending on the patient’s condition.

The recommended volume of intramuscular injection is 1-3 ml (50-150 mg). If necessary, repeated injections are given 2-3 days apart. In some patients, an additional injection may be prescribed 24-48 hours after the first injection.

When switching to oral treatment with Clopixol 2-3 days after the final injection of Clopixol-acufase (100 mg injections), the patient should be given an oral daily dose of 40 mg, in multiple doses if possible.

If necessary, the dose may be increased by 10-20 mg every 2-3 days to 75 mg/day or more.

Interaction

It increases the sedative effect of alcohol, barbiturates and other CNS depressants, reduces the effect of levodopa and other adrenergic agents.

Limits the hypotensive effect of guanethidine and its analogues.

The risk of extrapyramidal disorders increases with metoclopramide and piperazine.

Special Instructions

Malignant neuroleptic syndrome (MNS) is a rare but possible fatal complication of neuroleptic use.

The main characteristics of MNS are hyperthermia, muscle rigidity and impaired consciousness combined with autonomic nervous system dysfunction (labile blood pressure, tachycardia, increased sweating).

In addition to immediate discontinuation of neuroleptics, the use of general supportive measures and symptomatic treatment is essential.

Contraindications

Chronic hepatitis; severe cardiovascular disease.

Side effects

Extrapyramidal disorders, tardive dyskinesia, malignant neuroleptic syndrome, drowsiness, dizziness, dry mouth, accommodation disorders, urinary retention, constipation, tachycardia, orthostatic hypotension, changes in liver tests are possible.

Overdose

Symptoms: somnolence, hypo- or hyperthermia, hypotension, extrapyramidal symptoms, seizures, shock, coma .

Treatment: symptomatic and supportive.

Measures should be taken to maintain respiratory and cardiovascular activity.

Epinephrine (adrenaline) should not be used as it may cause a subsequent drop in blood pressure.

Convulsions can be controlled with diazepam and extrapyramidal symptoms with biperiden.

Pregnancy use

Contraindicated. Nursing mothers should stop breastfeeding.

Similarities

Clopixol, Clopixol Depot