Ciprofloxacin-ACOS, eye drops 0.3% 5 ml

Ciprofloxacin is a broad-spectrum antimicrobial drug from the group of fluoroquinolones. It inhibits bacterial enzyme DNA-gyrase, as a result DNA replication and synthesis of bacterial cell proteins are disrupted. It acts both on multiplying microorganisms and on those in a resting phase.

Pharmacodynamics

Active against Gram-negative aerobic bacteria: Enterobacteriaceae (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp, Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp.), other Gram-negative bacteria (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.); some intracellular pathogens (Legionella pneumophila, Brucella spp, Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium intracellulare); Gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Staphylococcus hominis), to a lesser extent – Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae). Most methicillin-resistant staphylococci are resistant to ciprofloxacin.

The sensitivity of the bacteria Streptococcus pneumoniae, Enterococcus faecalis is moderate.

The following bacteria are resistant to the drug: Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Clostridium difficile, Nocardia asteroides, Ureaplasma urealyticum. The action of the drug against Treponema pallidum has not been studied sufficiently.

Pharmacokinetics

The reported C_max in blood plasma when using eye drops is less than 5 ng/ml. The average concentration is less than 2.5 ng/mL.

Indications

Eye Infections, Blepharitis, Pain, Inflammatory Eye Diseases, Conjunctivitis

Infectious and Inflammatory Eye Diseases:

• acute and subacute conjunctivitis,
• blepharitis,
• keratitis,
• keratoconjunctivitis,
• chronic dacryocystitis,
• meibomitis,
• infective eye lesions after trauma or foreign body exposure.

Pre- and postoperative prevention of infectious complications in ophthalmic surgery.

Active ingredient

Ciprofloxacin

Composition

1 ml of eye drops contains:

Active substance:

ciprofloxacin 3 mg,

Associates:

Ethylenediaminetetetraacetic acid diatriic acid salt;

mannitol;

Anhydrous or 3-water sodium acetate;

Petter acetic acid;

Benzalkonium chloride;

Injectable water.

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