Chloropyramine, tablets 25 mg 20 pcs

Pharmacotherapeutic group

anti-allergic agent – Irhistamine receptor blocker

ATC code: D04AA09

Pharmacodynamics:

Chloropyramine, a chlorinated analog of tripelenamine (pyribenzamine), is an antihistamine drug belonging to the group of ethylenediamine antihistamines.

H1-histamine receptor blocker has antihistamine and m-cholinoblocking effects has antiemetic effect moderate antispasmodic and peripheral cholinoblocking activity Pharmacokinetics: When taken orally it is almost completely absorbed from the gastrointestinal tract. The therapeutic effect of chloropyramine develops within 15-30 minutes after oral administration and reaches a maximum during the first hour after ingestion and lasts for at least 3-6 hours. It is well distributed in the body including the central nervous system.

Indications

Active ingredient

Composition

1 tablet:

Active ingredient: chloroniramine hydrochloride – 25.0 mg.

Excipients: lactose monohydrate (milk sugar) – 130.0 mg, microcrystalline cellulose – 32.0 mg, sodium carboxymethyl starch – 5.0 mg, povidone-C25 – 6.0 mg, magnesium stearate – 2.0 mg.

How to take, the dosage

Overly with meals without chewing and with plenty of water.

Adults and adolescents from 14 years of age – 25 mg (1 tablet) 3-4 times a day (75-100 mg per day).

In children aged 3 to 6 years, 65 mg (1/4 tablet) 3 times a day or 125 mg (1/2 tablet)2 times a day.

Children aged 6 to 14 years – 125 mg (1/2 tablet) 2 to 3 times a day. Special groups of patients: Patients with impaired liver function: the dose may need to be reduced due to reduced metabolism of the active component of the drug in liver disease.

Patients with impaired renal function: the drug regimen and dose reduction may be required due to the fact that the active ingredient is mainly excreted through the kidneys.

The duration of treatment depends on the symptoms of the disease and its duration and course.

Interaction

Special Instructions

Chloropyramine may mask early signs of ototoxicity when combined with ototoxic drugs. Liver and kidney disease may require modification (reduction) of the drug dose. Taking the drug at night may increase the symptoms of reflux esophagitis. Simultaneous use of ethanol (alcoholic beverages) is unacceptable. Prolonged use of antihistamines may lead to disorders of hematopoiesis (leukopenia agranulocytosis thrombocytopenia hemolytic anemia). If during long-term treatment unexplained increase in body temperature is observed laryngitis pallor of skin jaundice formation of mouth ulcers appearance of hematomas unusual and prolonged bleeding should be tested to determine number of blood cells. If the test results indicate a change in blood count, the drug should be discontinued.

Chloropyramine especially in the initial period of treatment may cause drowsiness, fatigue and dizziness. Therefore, in the initial period, the duration of which is determined individually, it is prohibited to drive vehicles or perform work associated with an increased risk of accidents. Thereafter the degree of restriction to drive vehicles and work with mechanisms should be determined for each patient individually by the physician.

Contraindications

Hypersensitivity to chloropyramine and other ingredients of the drug pregnancy lactation period children under 3 years of age lactose intolerance lactase deficiency or glucose-galactase malabsorption bronchial asthma attack.

Closed-angle glaucoma urinary retention prostatic hyperplasia impaired hepatic and/or renal function gastric ulcer aggravated cardiovascular disease elderly patients emaciated patients respiratory failure concurrent administration of monoamine oxidase (MAO) inhibitors and other central nervous system depressant medications.

Side effects

– Central nervous system (CNS): drowsiness weakness fatigue dizziness headache nervous agitation tremor euphoria movement coordination disorders seizures encephalopathy.

– Gastrointestinal tract: abdominal discomfort pain in the upper abdomen dry mouth mucosa nausea vomiting diarrhea constipation loss or increase in appetite.

– Cardiovascular system: decreased blood pressure tachycardia arrhythmia.

– Eye: blurred vision glaucoma increased intraocular pressure.

– Blood disorders: leukopenia agranulocytosis hemolytic anemia and other pathological changes in the blood cell composition.

– Other: difficulty in urination urinary retention muscle weakness photosensitization allergic reactions.

If side effects occur, you should stop taking the drug and see a doctor immediately.

Overdose

Symptoms: in children – agitation anxiety hallucinations athetosis impaired movement coordination seizures dry mouth mucosa fixed dilated pupils hyperemia facial skin hyperemia sinus tachycardia urinary retention fever then – vascular collapse coma. In adults – lethargy anxiety impaired coordination of movement depression hyperthermia and hyperemia of the skin psychomotor agitation seizures postconvulsive depression coma.

Treatment: gastric lavage is necessary for up to 12 hours after taking the drug (note that gastric emptying is prevented by the anticholinergic effect of the drug). The use of activated charcoal is indicated (if detoxification is carried out early after oral administration). Monitoring of blood pressure and respiratory parameters is necessary. Symptomatic therapy (including administration of antiepileptic drugs caffeine) resuscitation measures artificial lung ventilation – as indicated. There is no specific antidote.

Pregnancy use

Chloropyramine is contraindicated in pregnancy.

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