Chloropyramine, 20 mg/ml 1 ml 5 pcs

Chloropyramine is a blocker of H1-histamine receptors. Its chemical structure is related to ethylenediamine derivatives. Chloropyramine selectively blocks H1-histamine receptors and reduces capillary permeability.

It prevents the development and facilitates allergic reactions. It has sedative, antihistamine, m-cholinoblocking and pronounced antipruritic effect. It has moderate antispasmodic and antiemetic activity.

Pharmacokinetics

It is evenly distributed in the body including the central nervous system. Penetrates through the blood-brain barrier. Binding of chloropyramine with blood plasma proteins is 7.9%. Peak binding is noted at pH 6.8-7.4.

Therapeutic concentration is retained for 4-6 hours. It is intensively metabolized in the liver.
It is eliminated mainly through the kidneys with the urine as metabolites. Excretion of chloropyramine in children may be faster than in adults.

Indications

• Treatment of symptoms of year-round and seasonal allergic rhinitis and allergic conjunctivitis;
• pollenosis (hay fever);
• tetritis;
• allergic dermatosis.
• allergic dermatoses;
• drug allergy;
• allergic reactions to insect bites;
• angioneurotic edema;
• serum disease.

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Active ingredient

Chloropyramine

Composition

1 ampoule (1 ml) contains the active ingredient chloropyramine hydrochloride (in terms of 100% of the substance) – 20 mg;
excipients: water for injection – up to 1 ml.

How to take, the dosage

Adults are prescribed 20-40 mg per day (contents of 1-2 ampoules).

Treatment in children starts with a dose of 5 mg (0.25 ml). Later the dose is increased depending on the age of the child.

In children aged 1-12 months, 5 mg (0.25 ml).

In children aged 1-6 years, 10 mg (0.5 ml).

In children aged 7-18 years, 10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg/kg body weight.

In severe allergies, treatment should be started with an injectable form of chloropyramine. At first it is given slowly intravenously, then it is transferred to intramuscular injection and in the final phase of treatment the tablets are taken orally. The duration of treatment is determined individually, depending on the clinical symptomatology and the condition of the patient.

Particular groups of patients

Elderly, frail patients: the use of chloropyramine requires particular caution because antihistamines more often cause side effects (dizziness, somnolence) in these patients.

Patients with impaired liver function: Dose reduction may be required due to reduced metabolism of the active component of the drug in liver disease.

Patients with impaired renal function: The route of administration and dose reduction may need to be changed because the active ingredient is mainly excreted through the kidneys.

Interaction

It enhances the effect of drugs for general anesthesia, sedatives, tranquilizers, m-cholinoblockers, opioid analgesics, local anesthetics.

Tricyclic antidepressants and monoamine oxidase inhibitors increase m-cholinoblocking and depressant effect on the central nervous system.

Caffeine and phenamine reduce the depressant effect on the central nervous system.
Simultaneous use with ethanol is not recommended (risk of severe CNS depression).

Special Instructions

At the time of treatment, consumption of alcoholic beverages is inadmissible. Taking the drug at night may worsen the symptoms of reflux esophagitis.

If during long-term use of the drug unexplained increase in body temperature, laryngitis, pale skin, jaundice, formation of oral mucous membrane ulcers, appearance of bruises, unusual and difficult to stop bleeding, a physician should be seen, since prolonged therapy with antihistamines may lead to hematopoiesis disorders.

The antihistamines may distort the manifestation of the reaction in skin allergy tests, so a few days before the planned test, the use of the drug should be discontinued. When combined with ototoxic drugs, chloropyramine may mask early manifestations of ototoxicity.