Cefecon D for children, rectal 250 mg 10 pcs

Indications

Cefekon D 250 mg is used in children from 3 to 12 years old as:

antipyretic for acute respiratory infections, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature;
analgesic for pain of mild to moderate intensity, incl. headache and toothache, muscle pain, neuralgia, pain from injuries and burns.

Pharmacological effect

Pharmaceutical group:

non-narcotic analgesic.

Pharmaceutical action:

Cefekon D is a non-narcotic analgesic that blocks COX1 and COX2 mainly in the central nervous system, affecting the centers of pain and thermoregulation.

In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect.

The absence of a blocking effect on the synthesis of Pg in peripheral tissues determines the absence of a negative effect on water-salt metabolism (retention of Na+ and water) and the mucous membrane of the gastrointestinal tract.

Special instructions

If fever persists for more than 3 days and pain persists for more than 5 days, you should consult your doctor.

The simultaneous use of paracetamol with other paracetamol-containing drugs should be avoided, as this may cause an overdose of paracetamol.

When using the drug for more than 5-7 days, peripheral blood counts and the functional state of the liver should be monitored.

Paracetamol distorts laboratory results in the quantitative determination of glucose and uric acid in plasma.

Active ingredient

Paracetamol

Composition

One suppository contains:

Active substance:

Paracetamol – 50 mg, 100 mg or 250 mg;

Basics for suppositories:

Solid fat (vitepsol, supposir) – until a suppository weighing 1.25 g is obtained.

Contraindications

Hypersensitivity to the components of Tsefekon D;
age up to 1 month of life.
With caution:
liver and kidney dysfunction;
Gilbert’s syndrome; Dubin-Johnson and Rotor;
diseases of the blood system (anemia, thrombocytopenia, leukopenia);
genetic absence of the enzyme glucose-6-phosphate dehydrogenase.

Side Effects

From the gastrointestinal tract: nausea, vomiting, abdominal pain.

Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, Quincke’s edema.

From the hematopoietic organs: anemia, leukopenia, agranulocytosis, thrombocytopenia.

With long-term use in large doses – hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.

Interaction

Stimulators of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase

production of hydroxylated active metabolites, which makes it possible to develop severe intoxications, even with a slight overdose.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity. When taken together with salicylates, the nephrotoxic effect of paracetamol increases.

Combination with chloramphenicol leads to an increase in the toxic properties of the latter. Strengthens the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.

Overdose

Symptoms:

during the first 24 hours after administration – pallor of the skin, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis.

Symptoms of liver dysfunction may appear 12-48 hours after an overdose.

In case of severe overdose – liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.

The hepatotoxic effect in adults occurs when taking 10 g or more.

Treatment:

administration of SH-group donors and precursors for the synthesis of glutathione – methionine 8-9 hours after an overdose and N-acetylcysteine ​​- after 12 hours.

The need for further therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.

Storage conditions

In a dry place, at a temperature not exceeding 20 °C

Shelf life

3 years

Manufacturer

Nizhpharm JSC, Russia