Cefecon D for children, rectal 100 mg 10 pcs
€1.92 €1.75
Pharmacodynamics:
Paracetamol has analgesic and antipyretic effects. The drug blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation.
In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the lack of a significant anti-inflammatory effect.
The lack of blocking effect on prostaglandin synthesis in peripheral tissues means it has no negative effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa.
Pharmacokinetics:
Absorption is high, quickly absorbed from the gastrointestinal tract. The period of reaching maximum concentration is 30-60 minutes.
It penetrates through the blood-brain barrier. The value of bioavailability in children and infants is similar to that in adults. It is metabolized in the liver.
Half-life period is 2-3 hours; within 24 hours, 85-95% of paracetamol is excreted by kidneys as glucuronides and sulfates; 3% of paracetamol is unchanged.
There is no significant age-related difference in the elimination rate of paracetamol and in the total amount of the drug excreted in the urine.
Indications
Active ingredient
Composition
One suppository contains:
The active ingredient:
Paracetamol – 50 mg, 100 mg or 250 mg;
Bases for suppositories:
The solid fat (vitepsol, souposir) – until you get a suppository weight of 1.25 g.
Cefecon® D rectal suppositories for children of 50 mg, 100 mg or 250 mg.
Five suppositories each in a contour cell pack;
Two contour cell packs together with the instructions for medical use of the drug are placed in the carton pack.
How to take, the dosage
Rectally, after purging enema or spontaneous bowel emptying. Dosage of Cefecon D is calculated depending on age and body weight, according to the table.
The average single dose is 10-15 mg/kg 2-3 times a day every 4-6 hours.
The maximum daily dose of paracetamol should not exceed 60 mg/kg.
1-3 months (4-6 kg) – 1 sup. 50 mg (50 mg);
3-12 months (7-10 kg) – 1 sup. 100 mg (100 mg);
1 to 3 years (11-16 kg) – 1-2 sups. 100 mg (100-200 mg) each;
3 to 10 years (17-30 kg) – 1 sip of 250 mg (250 mg);
10 to 12 years (31-35 kg) – 2 sips of 250 mg (500 mg).
Interaction
Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase
The production of hydroxylated active metabolites, which causes the possibility of severe intoxication, even with a small overdose.
Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects. When taken together with salicylates, the nephrotoxic effect of paracetamol increases.
Combination with chloramphenicol, increases the toxic properties of the latter. It enhances the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.
Special Instructions
Contraindications
Side effects
Gastrointestinal tract disorders: nausea, vomiting, abdominal pain.
Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, Quincke’s edema.
Hematopoietic disorders: anemia, leukopenia, agranulocytosis, thrombocytopenia.
In prolonged use in high doses – hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.
Overdose
Symptoms:
In the first 24 h after ingestion, skin pallor, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis.
The symptoms of hepatic dysfunction may appear 12-48 hours after overdose.
In severe overdose – hepatic failure with progressive encephalopathy, coma, death;
acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.
Hepatotoxic effect in adults occurs when taking 10 g or more.
Treatment: administration of SH-group donators and precursors of glutathione synthesis – methionine in 8-9 hours after overdose and N-acetylcysteine – in 12 hours.
The need for further therapeutic measures (further methionine administration, intravenous N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
Similarities
Weight | 0.023 kg |
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Shelf life | 3 years |
Conditions of storage | Keep out of reach of children, at a temperature not exceeding 20°C. |
Manufacturer | Nizhpharm AO, Russia |
Medication form | rectal suppositories |
Brand | Nizhpharm AO |
Other forms…
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