Bicillin-5, 1500000 units 10 ml

Pharmacotherapeutic group: Penicillin biosynthetic antibiotic

Pharmacokinetics

Indications

Infectious and inflammatory diseases caused by sensitive pathogens: long-term (year-round) prevention of relapses of rheumatism; syphilis, yaws; streptococcal infections (excluding infections caused by group B streptococci) – acute tonsillitis, scarlet fever, wound infections, erysipelas.

Pharmacological effect

Pharmacotherapeutic group: Antibiotic-biosynthetic penicillin

Pharmacokinetics

Special instructions

It cannot be administered subcutaneously, intravenously, endolumbarally, or into body cavities.

With accidental intravascular administration, transient feelings of depression, anxiety and visual disturbances (Wanier syndrome) may occur. In order to avoid accidental intravascular injection of the drug, it is recommended to perform aspiration before performing an intramuscular injection in order to detect possible needle entry into the vessel.

When treating syphilis, microscopic and serological studies are necessary before starting therapy and then for 4 months. Due to the development of fungal infections, it is advisable to simultaneously prescribe B vitamins and vitamin C, and, if necessary, antifungal drugs for systemic use. It must be taken into account that the use of insufficient doses or stopping treatment too early often leads to the emergence of resistant strains of pathogens.

Active ingredient

Benzathine benzylpenicillin, benzylpenicillin procaine

Composition

Benzathine benzylpenicillin – 1,200,000 units, benzylpenicillin novocaine salt (benzylpenicillin procaine) – 300,000 units.

Pregnancy

Bicillin®-5 penetrates in small quantities through the placental barrier and into mother’s milk. Use during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus.

It is recommended to stop breastfeeding if it is necessary to prescribe the drug.

Contraindications

Hypersensitivity to the drug, benzylpenicillin and other beta-lactam antibiotics. Lactation period.

With caution

Pregnancy, renal failure, severe allergy history, bronchial asthma, pseudomembranous colitis.

Side Effects

Allergic reactions: anaphylactic shock, anaphylactoid reactions, urticaria, fever, arthralgia, angioedema, exudative erythema multiforme, exfoliative dermatitis.

Laboratory indicators: anemia, thrombocytopenia, leukopenia, hypocoagulation.

Other: stomatitis, glossitis.

Interaction

Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) have a synergistic effect; bacteriostatic (including macrolides, chloramphenicol, lincosamides, tetracyclines) – antagonistic. Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the prothrombin index); reduces the effectiveness of oral contraceptives, drugs whose metabolism produces para-aminobenzoic acid, ethinyl estradiol – the risk of breakthrough bleeding.

Diuretics, allopurinol, tubular secretion blockers, phenylbutazone, non-steroidal anti-inflammatory drugs, reducing tubular secretion, increase the concentration of benzylpenicillin in the blood and tissues.

Allopurinol increases the risk of allergic reactions (skin rash).

Storage conditions

At a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after expiration date.

Manufacturer

Sintez, Russia