Bicillin-5, 1500000 units 10 ml
€6.41 €5.00
Pharmacotherapeutic group: Penicillin biosynthetic antibiotic
Pharmacokinetics
Indications
Infectious diseasesInfectious and inflammatory diseases caused by susceptible pathogens: prolonged (year-round) prevention of recurrent rheumatism; syphilis, yaws; streptococcal infections (excluding infections caused by group B streptococci) – acute tonsillitis, scarlet fever, wound infections, rust inflammation.
Active ingredient
Benzathine benzylpenicillin, benzylpenicillin procaine
Composition
Benzathine benzylpenicillin – 1200000 IU, benzylpenicillin novocaine salt (benzylpenicillin procaine) – 300000 IU.
How to take, the dosage
Intramuscularly.
Adults – 1200000 IU + 300000 IU once every 4 weeks.
Preschool children – 480000 IU + 120000 IU once every 3 weeks, children over 8 years – 960000 IU + 240000 IU once every 4 weeks.
The suspension is prepared using sterile water for injection, isotonic sodium chloride solution or 0.25-0.5% procaine (novocaine) solution.
Bicillin®-5 suspension is prepared aseptically, immediately before use (ex tempore): 5-6 ml of the solvent is slowly (at the rate of 5 ml in 20-25 seconds) injected into the vial with the drug under pressure. The contents of the vial is stirred and shaken along the longitudinal axis of the vial until a homogeneous suspension is formed. Bubbles are allowed on the surface of the suspension at the walls of the vial. Bicillin®-5 suspension is immediately after preparation deeply injected intramuscularly into the upper outer quadrant of the gluteal muscle. Stretching of the gluteal muscle after injection is not recommended. Delayed administration immediately after preparation alters the physical and colloidal properties of the suspension, which may result in difficulty in its movement through the syringe needle.
Interaction
Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) have a synergistic effect; bacteriostatic (including macrolides, chloramphenicol, lincosamides, tetracyclines) – antagonistic. Increases the effectiveness of indirect anticoagulants (by inhibiting the intestinal microflora, reduces the prothrombin index); reduces the effectiveness of oral contraceptives, drugs, metabolized by para-aminobenzoic acid, ethinylestradiol – the risk of bleeding “breakthrough”.
Diuretics, allopurinol, blockers of tubular secretion, phenylbutazone, non-steroidal anti-inflammatory drugs, reducing tubular secretion, increase the concentration of benzylpenicillin in blood and tissues.
Allopurinol increases the risk of allergic reactions (skin rash).
Special Instructions
It should not be administered subcutaneously, intravenously, endolumbally, or in body cavities.
Inadvertent intravascular administration may cause transient feelings of depression, anxiety and visual disturbances (Wanier syndrome). In order to avoid accidental intravascular injection, aspiration is recommended prior to intramuscular injection in order to detect possible needle entry into the vessel.
In syphilis treatment, microscopic and serologic studies should be performed before starting therapy and then for 4 months. In connection with the development of fungal infections, it is advisable to simultaneously prescribe B-group vitamins and vitamin C, and, if necessary, antifungal drugs for systemic use. It should be taken into account that the use of insufficient doses or too early discontinuation of treatment often leads to the emergence of resistant strains of pathogens.
Contraindications
Hypersensitivity to the drug, benzylpenicillin and other beta-lactam antibiotics. Period of lactation.
With caution
Pregnancy, renal failure, history of allergy, bronchial asthma, pseudomembranous colitis.
Side effects
Allergic reactions: anaphylactic shock, anaphylactoid reactions, urticaria, fever, arthralgia, angioedema, erythema multiforme exudative, exfoliative dermatitis.
Laboratory findings: anemia, thrombocytopenia, leukopenia, hypocoagulation.
Others: stomatitis, glossitis.
Pregnancy use
Bicillin®-5 in small amounts penetrates through the placental barrier and into the mother’s milk. Administration during pregnancy is possible only when the estimated benefit to the mother exceeds the potential risk to the fetus.
It is recommended to stop breastfeeding if the drug has to be administered.
Weight | 0.016 kg |
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Shelf life | 3 years. Do not use after the expiration date. |
Conditions of storage | At a temperature not exceeding 25 ° C. Store out of the reach of children. |
Manufacturer | Sintez OAO, Russia |
Medication form | Powder for preparation of solution |
Brand | Sintez OAO |
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